Bio Basic - P0319.SIZE.25MU - Polymyxin B Sulfate, 25MU

ITEM #: 12934621
Polymy x in B sulfate: Polymy x in B sulfate (PMB) is a strongly cationic cyclic polypeptide antibiotic isolated from fermentation of Bacillus polymy x a. PMB is a variable mi x ture of B1 and B2 (predominantly B1).
Polymy x ins combine with cell membranes and disrupt normal permeability to small molecules. Polymy x in B and the other polymy x in antibiotics act primarily by binding membrane phospholipids and disrupting the cytoplasmic membrane, inducing pore formation in bacterial walls (large enough to permit nucleotide leakage). Polymy x in B binds to the lipid-A portion of the lipopolysaccharide in the cell membrane of Gram-negative bacteria.
The interaction involves ionic forces between amino groups in Polymy x in B and phosphate and carbo x yl groups in the lipid A-Kdo region, with hydrophobic interactions between the respective acyl groups.
Data suggest a stoichiometric binding of one LPS monomer to one polymy x in B molecule. “Polymy x in B has a bactericidal action on most Gram-negative bacilli (E. coli, e.g.) e x cept proteus spp. ... not active against Neisseria species, ... most fungi and Gram-positive bacteria."
Activity is inhibited by iron (II), Co (II), Mn (II) and magnesium ions. Polymy x in B may be incompatible with other microbial agents, including amphotericin, cephalothin sodium, cephasolin sodium, chloramphenicol sodium succinate and tetracycline hydrochloride; it is also incompatible with heparin sodium and prednisolone sodium phosphate
Polymyxin B Sulfate, 25MU
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