Bio Basic - RC216-14.SIZE.1MG - Insulin-like Growth Factor-1; Human IGF-1, 1mg

ITEM #: 12935082
IGF-1, Insulin-like Growth factor-1, human: Human IGF-I
The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. The liver predominantly produces iGFs, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and rela x in. The IGFs are similar by structure and function to insulin but have a much higher growth-promoting activity than insulin. IGF-II e x pression is influenced by placenta lactogen, while IGF-I e x pression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions, generates mature IGFs. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.
Source: Escherichia coli.
Molecular Weight: Appro x imately 7.6 kDa, a single non-glycosylated polypeptide chain containing 70 amino acids.
Quantity: 20ug/100ug/500ug/1000ug/Bulk
Purity: >95% by SDS-PAGE and HPLC analyses.
Biological Activity: Fully biologically active when compared to standard. The ED50 was determined by a cell proliferation assay using FDC-P1 cells is 5 x 105 units/mg.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation: Lyophilized from a 0.2mm filtered concentrated (1mg/ml) solution in PBS, pH 7.4.
AA Sequence: GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA
Endoto x in: Less than 1EU/mg of rHuIGF-I as determined by LAL method.
Insulin-like Growth Factor-1; Human IGF-1, 1mg
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