Cytiva - 17543803 - MabSelect SuRe, 1 LItem must be purchased in units of 1

ITEM #: 12915239
The recombinant protein A ligand of Mab. Select Su. Re has been engineered to withstand 0.1-0.5 M NaOH, enabling efficient cleaning of the chromatography resin.

• In process-scale applications, this NaOH tolerance extends the lifetime of the resin and allows for the use of rigorous and cost-effective CIP and sanitization protocols.
• In research applications, this NaOH tolerance enables the purification of multiple antibody types with minimized cross-contamination risk.
• Protein ligand designed for enhanced protease resistance compared with unmodified protein A leads to lower ligand leakage.
• Meets industrial demands in terms of comprehensive technical and regulatory support and security of supply.
• Animal-component free raw materials and manufacturing process.

Mab. Select Su. Re resin properties

This resin for monoclonal antibody (m. Ab) purification contains a rigid, high-flow agarose matrix that delivers excellent pressure/flow properties. Like many of protein A chromatography resins, Mab. Select Su. Re uses oriented ligand coupling for excellent binding capacity. It exhibits low nonspecific protein binding, thereby decreasing impurity levels in the eluate pool. Benefits of alkali-tolerant protein A ligand

Mab. Select Su. Re resin features an engineered, alkali-tolerant r. Protein A ligand for m. Ab purification. The ligand provides greater stability than conventional protein A affinity resins in the alkaline conditions used in cleaning-in-place (CIP) and sanitization protocols. The resin can withstand rigorous CIP and sanitization procedures with 0.1 to 0.5 M NaOH. The enhanced alkali stability of this resin improves process economy and product quality; cleaning can be performed with cost-effective reagents such as sodium hydroxide, eliminating the need for expensive and hazardous cleaning agents such as Gua-HCl.Generic elution conditions for different m. Abs

Mab. Select Su. Re resin offers generic elution conditions for different monoclonal antibodies, which is an advantage when designing purification platform processes. This feature is also correlated to the construction of the r. Protein A ligand, which has a reduced interaction with the VH3 (Fab) domain present in human antibodies.Compatible empty columns – bioprocess scale

For process-scale applications, recommends Axi. Chrom chromatography columns for the Mab. Select family of products.Convenient prepacked columns – research scale

This chromatography resin is also available in the following formats:

• Hi. Trap Mab. Select Su. Re: convenient for easy use with a syringe, peristaltic pump, and chromatography system
• Hi. Screen Mab. Select Su. Re for method and process development
• Pre. Dictor Mab. Select Su. Re 96-well filter plate for high-throughput screening or process development
• Pred. Dictor Robo. Columns Mab. Select– miniaturized column format for high-throughput process development

Convenient prepacked columns – bioprocess scale

Prepacked ReadyTo. Process columns are available, eliminating the need for column packing and cleaning validation.
This listing is for package of 1 L.