Cytiva - 17547402 - MabSelect SuRe LX, 200 mL Item must be purchased in units of 1

ITEM #: 3547841
Mab. Select Su. Re LX is a protein A affinity resin with very high dynamic binding capacity at extended residence times. The chromatography resin is developed for processing of monoclonal antibodies at high titers.

• Novel, alkali-tolerant r. Protein A ligand withstands rigorous clean-in-place and sanitization procedures with 0.1 to 0.5 M NaOH.
• High dynamic binding capacity (DBC) for high titer cultures reduces process time and amount of resin used.
• Fulfills industrial demands for security of supply, robust performance, and regulatory support.

Excellent for antibody purification in bioprocess applications

Alkali tolerance, high capacity and low ligand leakage in combination with the rigid base matrix makes Mab. Select Su. Re LX an excellent choice for purification of monoclonal antibodies for clinical applications. Part of the Mab. Select protein A resin family

Mab. Select Su. Re LX is a member of the Mab. Select family of protein A resins for the capture of monoclonal antibodies at process scale. Mab. Select Su. Re LX shares features and benefits of Mab. Select and Mab. Select Su. Re such as a rigid, high-flow agarose matrix that ensures excellent pressure/flow properties, low non-specific binding that leads to low impurity levels in the eluate pool, and an oriented ligand coupling for excellent binding capacity. It also features the same alkali-tolerant r. Protein A ligand as Mab. Select Su. Re. This protein ligand provides greater stability than conventional protein A-based resins in the alkaline conditions used in cleaning-in-place (CIP) and sanitization protocols.Enhanced stability of the protein ligand

The enhanced alkali stability of Mab. Select Su. Re LX improves process economy and product quality; cleaning can be performed with cost-effective reagents such as sodium hydroxide, eliminating the need for expensive and hazardous cleaning agents such as Gua-HCl. Process economy is also improved by the increased dynamic binding capacity of Mab. Select Su. Re LX.
Just as for Mab. Select Su. Re, the novel ligand construct of Mab. Select Su. Re LX has been proven to have an increased stability towards proteases. Therefore, the level of leakage of the Mab. Select Su. Re LX ligand during elution is low.Purification platform design advantage

Mab. Select Su. Re has been demonstrated to give generic elution conditions for different monoclonal antibodies, which can be applied also to Mab. Select Su. Re LX as it utilizes the same ligand. This is an advantage when designing generic purification platform processes. The feature is also correlated to the construction of the Mab. Select Su. Re protein ligand.Prepacked columns and predictor filter plates.

Mab. Select Su. Re LX is available in the following formats:Process development scale – prepacked columns and plates

• Pre. Dictor Mab. Select Su. Re LX – 96-well plates for high-throughput screening or process development.
• Pre. Dictor Robo. Column Mab. Select Sure LX – miniaturized column format for high-throughput process development.
• Hi. Screen Mab. Select Su. Re LX columns – optimized for method and process development.

Lab/research scale – prepacked columns for manual protein purification

Hi. Trap Mab. Select Su. Re LX chromatography columns – for easy use with a syringe, peristaltic pump, or chromatography system.Lab/research scale – prepacked columns for automated protein purification and analysis

Hi. Trap Mab. Select Su. Re LX chromatography columns – for easy use with a syringe, peristaltic pump, or chromatography system.Process scale protein purification – prepacked columns

ReadyTo. Process Mab. Select Su. Re LX columns – 1 L and larger chromatography columns for clinical manufacturing that avoid the need for cleaning and cleaning validation.
For samples, contact your local sales representative or customer support.
Mab. Select Su. Re LX protein A resin builds on the proven track record of Mab. Select and Mab. Select Su. Re resins in downstream processing of monoclonal antibodies.
This listing is for package of 200 mL.