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Cytiva - 17548115 - HiScreen Capto Core 700Item must be purchased in units of 1

  • MFR SKU: 17548115
  • ITEM #: 12218894
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ITEM #: 12218894
Capto Core 700 is designed for intermediate purification and polishing of viruses and other large biomolecules. The novel core bead technology and multimodal, octylamine ligand give Capto Core 700 dual functionality, size exclusion, and binding chromatography in one chromatography medium (resin).
  • For intermediate purification and polishing of viruses and other large biomolecules (Mr > 700 000) in flowthrough mode.
  • Novel core bead technology allows efficient capture of contaminants...
ITEM #: 12218894
Capto Core 700 is designed for intermediate purification and polishing of viruses and other large biomolecules. The novel core bead technology and multimodal, octylamine ligand give Capto Core 700 dual functionality, size exclusion, and binding chromatography in one chromatography medium (resin).
  • For intermediate purification and polishing of viruses and other large biomolecules (Mr > 700 000) in flowthrough mode.
  • Novel core bead technology allows efficient capture of contaminants while target molecules are collected in the flowthrough.
  • Significantly improved productivity and higher flow rates compared with gel filtration methods.
  • Straightforward optimization due to flowthrough chromatography and robust performance.
  • Convenient small-scale purification, process development, and scale-up using prepacked Hi. Trap and Hi. Screen columns.
Capto Core 700 is composed of a ligand-activated core and inactive shell. The inactive shell excludes large molecules (cut off ~ Mr 700 000 [700 k. Da]) from entering the core through the pores of the shell. These larger molecules are collected in the column flowthrough while smaller impurities bind to the internalized ligands. The core of each bead is functionalized with ligands that are both hydrophobic and positively charged, resulting in a highly efficient multimodal binding of various contaminants small enough to enter the core. The multimodal ligands ensure strong binding with most impurities over a wide range of pH and salt concentrations. Bound impurities are removed from the beads by cleaning-in-place (CIP) procedures using NaOH and in most cases, a solvent. Capto Core 700 is available in various pack sizes for packing columns and in convenient, prepacked 1 ml Hi. Trap and 4.7 ml prepacked Hi. Screen formats. Hi. Trap and Hi. Screen columns can be connected in series for increased capacity and are convenient to use when developing an efficient and robust separation method.
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Cytiva - 17548115 - HiScreen Capto Core 700Item must be purchased in units of 1

  • Item #: 12218894
  • MFR SKU: 17548115
Technical Specs
  • Bed Dimensions: 7.7 mm × N/A
  • Bed Volume: 4.7 ml
  • Pressure Max. [Over the Packed Bed During Operation]: N/A (N/A)
  • BioProcess resin: Yes
  • Ligand: Octylamine
  • Particle size, d50V: 90 µm1)
  • Matrix: Highly cross-linked agarose
  • Binding Capacity/ml Chromatography Medium: ~ 13 mg ovalbumin2)
  • PH Stability Working Range: 3-133)
  • PH stability, CIP: 2-144)
  • Storage Conditions: 4 to 30°C, 20% Ethanol
  • Chemical Stability: All commonly used aqueous buffers,1 M sodium hydroxide6, 6 M guanidine hydrochloride, 30% isopropanol, and 70% ethanol5)
  • Avoid Using: Oxidizing agents, citrate buffers6)
  • Molecular Weight [MW] Cut: Mr ~700 000
  • Column i.d.: 7.7 mm
  • Complete Packsize: 1 Piece
  • Material [Column Hardware]: Polypropylene (PP)
  • Material [Column Tube]: Polypropylene (PP)
  • Bed Support: Filter
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