Integrated BioTherapeutics - 0260-001 - Human anti-EBOV GP mAb (KZ52), 100ug

ITEM #: 12981469
Immunogen: The human antibody KZ52 was derived from a human convalescent patient who survived an Ebola virus (EBOV) infection. KZ52 is directed towards the EBOV glycoprotein (GP).
Description: Protein A purified neutralizing human monoclonal antibody reactive to EBOV GP (Parren et al). The antibody detects recombinant EBOV GP without the transmembrane region (EBOV rGPΔTM) e x pressed in both mammalian and insect cells.
Supplied: 100 µg is supplied in buffer containing Histidine, sodium chloride and sucrose at a concentration of 1.732 mg/mL. No preservative is added.
Purification: Antibody is purified using immobilized protein A.
Clonality: Human variable, human constant of the IgG1 isotype.
Relevance: The antibody can be used for detection of EBOV GP.
Recommended Dilutions:
ELISA: Assay-dependent dilution. Internal QC demonstrates good detection of recombinant EBOV GP coated to a microtiter plate at 1 µg/mL when using KZ52 mAb at a concentration between 10 - 0.001 µg/mL.
Neutralization Assay: KZ52 lot 1605006 showed similar neutralization activity compared to KZ52 reference lot 1603003.
WB: Not suitable for Western Blot analysis.
Storage: 2-3 weeks +4°C, -20°C long term. Avoid repeated freeze/thaws.
Cross Reactivity: No cross-reactivity was observed to Sudan Virus (SUDV) or Marburg Virus (MARV) GP or virus-like particles (VLPs).
Intended for research use only, not for human, therapeutic, or diagnostic applications.
Human anti-EBOV GP mAb (KZ52), 100ug
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