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LKT Laboratories - A6017-2.5 MG - Apelin receptor agonist involved in vascular contraction, water homeostasis, and feeding behavior. It decreases brain edema, increases myocardial glucose uptake, and stimulates tube formation in myocardial microvascular

  • MFR SKU: A6017-2.5 MG
  • ITEM #: 13001495
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ITEM #: 13001495
Apelin-13 is an endogenous peptide that e x hibits neuroprotective and pro-angiogenic activities. Apelin-13 binds apelin receptors (APJ receptors) that heterodimerize with bradykinin receptors; upon binding, this comple x signals for increases in phosphorylation of eNOS, activation of PKC, and cellular proliferation. Apelin-13 is also involved in the regulation of water balance, food intake, nociception, and cardiovascular responses. In vivo and in vitro, apelin-13 increases myocardial glucose uptake...
ITEM #: 13001495
Apelin-13 is an endogenous peptide that e x hibits neuroprotective and pro-angiogenic activities. Apelin-13 binds apelin receptors (APJ receptors) that heterodimerize with bradykinin receptors; upon binding, this comple x signals for increases in phosphorylation of eNOS, activation of PKC, and cellular proliferation. Apelin-13 is also involved in the regulation of water balance, food intake, nociception, and cardiovascular responses. In vivo and in vitro, apelin-13 increases myocardial glucose uptake and GLUT4 membrane translocation in an AMPK-dependent manner. In animal models of ischemia/reperfusion, apelin-13 decreases neurological deficits, infarct volume, and brain edema, and also downregulates e x pression of Ba x and caspase 3 through activation of the PI3K/Akt signaling pathway. Additionally, apelin-13 promotes proliferation, migration, and tube formation in myocardial microvascular endothelial cells.
Grade: ≥95%
Apelin receptor agonist involved in vascular contraction, water homeostasis, and feeding behavior. It decreases brain edema, increases myocardial glucose uptake, and stimulates tube formation in myocardial microvascular endothelial cells.
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LKT Laboratories - A6017-2.5 MG - Apelin receptor agonist involved in vascular contraction, water homeostasis, and feeding behavior. It decreases brain edema, increases myocardial glucose uptake, and stimulates tube formation in myocardial microvascular

  • Item #: 13001495
  • MFR SKU: A6017-2.5 MG
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