LKT Laboratories - B8277-5 MG - Found in Rhus verniciflua and Butea monosperma. It induces cell cycle arrest and apoptosis in lung cancer cells, inhibits vessel sprouting from aortic rings, and prevents hepatic stellate cell activation.

ITEM #: 13000386
Butein is a flavonoid originally found in the bark of Rhus verniciflua and the flowers of Butea monosperma. Butein e x hibits anticancer chemotherapeutic, anti-angiogenic, neuroprotective, anti-inflammatory, antio x idative, and anti-fibrotic activities. In lung cancer cells, butein decreases e x pression of COX-2, inducing cell cycle arrest and apoptosis; this compound also inhibits tumor growth of prostate cancer x enografts in vivo. Butein inhibits phosphorylation of Akt, mTOR, and their downstream targets and suppresses VEGF-induced cell proliferation, migration, and tube formation in endothelial progenitor cells; it also inhibits vessel sprouting from aortic rings in vivo. In animal models of spinal cord injury, butein decreases e x pression of NF-?B and I?Ba, inhibits activation of caspase 3, and suppresses infiltration of neutrophils. In cellular models, this compound increases levels of glutathione and activity of catalase and glutathione S-transferase and decreases levels of lactate dehydrogenase. Butein also acts as a free radical scavenger. Additionally, butein prevents hepatic stellate cell (HSC) activation, downregulating e x pression of TGF-ß, TIMP-1/2, and MMP-2 and inhibiting activation of NF-?B, p38, JNK, and Smad3.
Grade: ≥98%
Found in Rhus verniciflua and Butea monosperma. It induces cell cycle arrest and apoptosis in lung cancer cells, inhibits vessel sprouting from aortic rings, and prevents hepatic stellate cell activation.
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