LKT Laboratories - C0033-50 MG - Semi-synthetic derivative of cafestol, a natural product found in brewed, unfiltered coffee. Inhibitor of ERK2 and MEK1, agonist at FXR and PXR receptors. It displays a wide variety of biological activities, including

ITEM #: 13000428
Cafestol is a diterpene found in brewed, unfiltered coffee that e x hibits anti-angiogenic, anticancer, chemopreventive, neuromodulatory, anti-inflammatory, and hyperlipidemic activities. Cafestol inhibits proliferation, migration, and tube formation in vitro, potentially through decreasing phosphorylation of FAK and Akt. In renal carcinoma cells, cafestol induces G1 phase cell cycle arrest and apoptosis, decreases the mitochondrial membrane potential, increases activation of caspase 3, downregulates e x pression of Bcl-2, Bcl-cl, Mcl-1, and FLIP, suppresses Akt pathway signaling, and inhibits cellular proliferation. In other cellular models, cafestol decreases aflato x in B1-induced DNA adduct formation and increases levels of glutathione-S-transferase. Additionally, cafestol activates Nrf2 and displays protective benefit in models of Parkinson’s disease. In LPS-stimulated macrophages, this compound inhibits ERK2 and MEK1 and decreases production of COX-2 and prostaglandin E2 (PGE2). In vivo, cafestol upregulates e x pression of genes involved in cholesterol homeostasis by acting as an agonist at the farnesoid X receptor (FXR) and pregnane X receptor (PXR).
Grade: ≥98%
Semi-synthetic derivative of cafestol, a natural product found in brewed, unfiltered coffee. Inhibitor of ERK2 and MEK1, agonist at FXR and PXR receptors. It displays a wide variety of biological activities, including inhibiting angiogenesis, inducing apo
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