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Merck - 100105-50MG - A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem

  • MFR SKU: 100105-50MG
  • ITEM #: 3441722
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ITEM #: 3441722
A23187, Free Acid, Streptomyces chartreusensis^ (Calcimycin) Mobile ion-carrier that forms stable complexes with divalent cations. Purity: >=98% by TLC. Soluble in DMSO and methanol. CAS: 52665-69-7. FW: 523.6. White solid, 50mg.
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Merck - 100105-50MG - A23187, Free Acid, <i>Streptomyces chartreusensis</i> - CAS 52665-69-7 - Calbiochem

  • Item #: 3441722
  • MFR SKU: 100105-50MG
  • Overview A mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca 2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
  • Catalogue Number 100105
  • Brand Family Calbiochem®
  • Synonyms Calcimycin
  • References Caron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
  • Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
  • Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
  • Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
  • Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.
  • CAS number 52665-69-7
  • ATP Competitive N
  • Form White solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Mitochondrial ATPase
  • Purity ≥ 98% by TLC
  • Cell permeable N
  • RTECS DM4676000
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 2 months at -20° C.

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