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Merck - 1016970010 - 1016970010 Benzonase(R) endonuclease EMPROVE(R) Expert

  • MFR SKU: 1016970010
  • ITEM #: 7028831
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ITEM #: 7028831
Benzonase endonuclease acts as an unspecific endonuclease, degrading both DNA and RNA to small 3-5 base pairs (< 6 kDa) fragments with no base preference. It is the ideal tool for nucleic acid removal in virus vector and vaccine manufacturing as demanded by regulators. Additionally, the use of Benzonase endonuclease increases the yield in virus purification, protects downstream chromatography and filter devices from fouling, and reduces feed stream endonuclease is the smart solution for DNA removal...
ITEM #: 7028831
Benzonase endonuclease acts as an unspecific endonuclease, degrading both DNA and RNA to small 3-5 base pairs (< 6 kDa) fragments with no base preference. It is the ideal tool for nucleic acid removal in virus vector and vaccine manufacturing as demanded by regulators. Additionally, the use of Benzonase endonuclease increases the yield in virus purification, protects downstream chromatography and filter devices from fouling, and reduces feed stream endonuclease is the smart solution for DNA removal in viral vaccine and viral vector production and has proven its value for over 30 years. Balancing efficiency and regulatory compliance by delivering reliability and high-quality due manufacturing under good manufacturing practices (GMP ICH Q7). Our e x tensive documentation packages of Emprove dossiers and the availability of a FDA Drug Master File type II, supports you in filing your vaccine manufacturing process to the authorities.
Synonyms: Endonuclease from Serratia marcescens
MDL Number: MFCD00131010
Application: Used for the removal of nucleic acid from protein samples.
Biochem Physiol Actions: Digests native or heat-denatured DNA and RNA.
: Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
1016970010 Benzonase(R) endonuclease EMPROVE(R) Expert
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Merck - 1016970010 - 1016970010 Benzonase(R) endonuclease EMPROVE(R) Expert

  • Item #: 7028831
  • MFR SKU: 1016970010
Technical Specs
  • Catalogue Number 101697
  • HS Code 3507 90 90
  • Quality Level MQ500
  • pH value 8.0 (HO, 25 ° C)
  • Storage class 10 - 13 Other liquids and solids
  • WGK WGK 1 slightly hazardous to water
  • Storage Store at -20° C. Transport with dry ice.
  • Declaration (railroad and road) ADR, RID Kein Gefahrgut
  • Declaration (transport by air) IATA-DGR UN 1845 , 9,
  • Declaration (transport by sea) IMDG-Code UN 1845 , 9,
  • Appearance (description) clear
  • Appearance (color) colorless
  • Activity (DNA; pH8.0; 30min; 37° C) ≥ 250 U/µl
  • Spec. activity (calc. on protein) ≥ 1.1E+06 U/mg
  • Identity (electrophoresis) passes test
  • Purity (calc. on protein) ≥ 99.0 %
  • Proteases not detectable
  • Al (Aluminium) ≤ 50 ppm
  • Co (Cobalt)* ≤ 0.5 ppm
  • Cr (Chromium)* ≤ 110 ppm
  • Cu (Copper)* ≤ 30 ppm
  • Fe (Iron) ≤ 130 ppm
  • Mn (Manganese) ≤ 25 ppm
  • Mo (Molybdenum)* ≤ 150 ppm
  • Ni (Nickel)* ≤ 2 ppm
  • Zn (Zinc) ≤ 130 ppm
  • Colony count (aerobic bacteria) ≤ 10 CFU in 100 000 U
  • Colony count (Yeasts and moulds) ≤ 10 CFU in 100 000 U
  • Endotoxines (LAL-test) ≤ 0.25 EU in 1000 U
  • Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not
  • likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
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