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Merck - 1043529010 - L-HISTIDINE SUITABLE FO (10KG) (Each)

Name: Merck - 1043529010 - L-HISTIDINE SUITABLE FO (10KG) (Each)
SKU: 1043529010
Price: 10041.2 USD
Availability: InStock

Lists At: $13,372.11 You Save: $3,330.91

$10,041.20

Stock Status: SHIPS SOON (reserve your unit today)
Average lead time for this brand: 2-3 weeks. Specific products may vary.

ITEM #: 7028951
L-histidine suitable for use as excipient EMPROVE exp PH EUR, USP^ 10kg
This listing is for Each

Catalogue Number 104352
Synonyms His
CAS number 71-00-1
EC number 200-745-3
Grade Ph Eur, ChP, JP, USP
Hill Formula CHNO
Molar Mass 155.16 g/mol
HS Code 2933 29 90
Structure formula Image
Quality Level MQ500
Density 1.449 g/cm3 (20 ° C)
Melting Point 285 ° C (decomposition)
pH value 7.0 - 8 (15.5 g/l, HO, 25 ° C)
Bulk density 430 kg/m3
Solubility 38.2 g/l
LD 50 oral LD50 Rat > 5110 mg/kg
RTECS MS3070000
Storage class 10 - 13 Other liquids and solids
WGK WGK 1 slightly hazardous to water
Storage Store at +2° C to +30° C.
Assay (acidimetric, calculated on dried substance) 98.5 - 101.0 %
Assay (perchloric acid titration, calculated on dried substance) 99.0 - 101.0 %
Identity (IR-spectrum) passes test
Identity (specific rotation) passes test
Identity (TLC) passes test
Appearance white to almost white fine-crystalline powder or colorless crystals
Appearance of solution (50 g/l; water) clear and not more intense in color than reference solution BY.
Appearance of solution (20g/l, water) clear and colorless
Transmittance of solution (30 g/l, water) ≥ 98.0 %
Spec. rotation (α 20/D, 110g/l, hydrochloric acid 120g/l, calc. on dried substance) +11.4 to +12.4

Spec. rotation (α 25/D, 110g/l, hydrochloric acid 6mol/l, calc. on dried substance) +12.6 to +14.0
Spec. rotation (α 20/D, 110g/l, hydrochloric acid6mol/l, calc. on dried substance) +12.0 to +12.8
pH (20g/l, CO-free water) 7.0 - 8.5
Acidity (20g/l, water) 7.0 - 8.5
Chloride (Cl) ≤ 200 ppm
Sulfate (SO) ≤ 200 ppm
Heavy metals (as Pb) ≤ 10 ppm
As (Arsenic) ≤ 1 ppm
Cu(Copper) ≤ 25 ppm
Fe (Iron) ≤ 10 ppm
Mn (Manganese) ≤ 25 ppm
Zn (Zinc) ≤ 130 ppm
Other amino acids (TLC) ≤ 0.5 %
Related Compounds, total (TLC) ≤ 0.5 %
Related substances (TLC) passes test
Ninhydrin-positive substances (LC) (any ninhydrin-positive impurity) ≤ 0.2 %
Ninhydrin-positive substances (LC) (ammonium (570 nm)) ≤ 0.02 %
Ninhydrin-positive substances (LC) (total impurities) ≤ 0.5 %
Residual solvents (ICH (Q3C)) excluded by manufacturing process
Sulfated ash (600° C) ≤ 0.1 %
Loss on drying (105 ° C; 3h) ≤ 0.2 %
Bacterial endotoxins < 2.0
Bacterial endotoxins (ChP) < 6.0
Microbiological test (total aerobic microbial count (TAMC)) ≤ 10²
Microbiological test (total yeast and mould count (TYMC)) ≤ 10²
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
Corresponds to Ph.Eur., ChP, JP, USP

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