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Merck - 110145-5MG - D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem

  • MFR SKU: 110145-5MG
  • ITEM #: 3029621
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ITEM #: 3029621
D-erythro-Sphingosine, N-Acetyl-^ (C2 Ceramide). Biologically active, cell-permeable, non-physiological ceramide analog. Inhibits cell growth and induces apoptosis in HL-60 cells. Purity: >=98% by TLC. Soluble in DMSO, ethanol. FW: 341.5. White to off-white solid, 5mg.
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Merck - 110145-5MG - D-<i>erythro</i>-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem

  • Item #: 3029621
  • MFR SKU: 110145-5MG
  • Overview Biologically active, cell-permeable, non-physiological ceramide analog. Inhibits cell growth and induces apoptosis in HL-60 cells. Induces intranucleosomal DNA fragmentation. An activator of heterotrimeric protein phosphatase 2A (PP2A). Stimulates a cytosolic serine/threonine protein phosphatase in T9 cells at concentrations as low as 100 nM. Activates stress activated protein kinase (SAPK) in HL-60 human promyelocytic cells.
  • Catalogue Number 110145
  • Brand Family Calbiochem®
  • Synonyms C Ceramide
  • References Westwick, J.K., et al. 1995. J. Biol. Chem. 270, 22689.
  • Cifone, M.G., et al. 1994. J. Exp. Med. 180, 1547.
  • Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
  • Bielawska, A., et al. 1993. J. Biol. Chem. 268, 26226.
  • Obeid, L.M., et al. 1993. Science 259, 1769.
  • Ballou, L.R., et al. 1992. J. Biol. Chem. 267, 20044.
  • Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.
  • CAS number 3102-57-6
  • ATP Competitive N
  • Form White to off-white solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Inhibits cell growth and induces apoptosis in HL-60 cells
  • Purity ≥ 98% by TLC
  • Cell permeable Y
  • R Phrase R: 36/37/38
  • Irritating to eyes, respiratory system and skin.
  • S Phrase S: 26-36
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Irritant
  • Storage -20° C
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). DMSO stock solutions are stable for up to 1 month at -20° C. Alcohol stock solutions are stable for

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