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Merck - 116890-5MG - Adenosine Kinase Inhibitor | CAS 214697-26-4 | Calbiochem | 5MG

  • MFR SKU: 116890-5MG
  • ITEM #: 6281841
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ITEM #: 6281841
The Adenosine Kinase Inhibitor, also referenced under CAS 214697-26-4, controls the biological activity of Adenosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
This listing is for 5 mg Plastic ampoule

Merck - 116890-5MG - Adenosine Kinase Inhibitor | CAS 214697-26-4 | Calbiochem | 5MG

  • Item #: 6281841
  • MFR SKU: 116890-5MG
Technical Specs
  • Overview A cell-permeable, non-nucleoside pyridopyrimidine compound that acts as a potent, adenosine-competitive, and reversible adenosine kinase (AK) inhibitor (IC 50 = 50.7 nM using intact IMR-32 cells and 1.7 nM in cell-free assays using rat brain cytosolic AK). The inhibitory effect is not species-specific and its pharmacological selectivity is confirmed using a panel of more than 80 other enzymes, ion channels, and receptors, including various adesine receptors. It readily crosses the blood-brain barrier and is shown to be efficacious in in vivo animal models via various administration methods (i.p., p.o., s.c.).
  • Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without salt molecules.
  • Catalogue Number 116890
  • Brand Family Calbiochem®
  • Synonyms 4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2, 3-d]pyrimidine, 2HCl, ABT-702
  • References De Vry, J., et al. 2004. Eur. J. Pharmacol. 491, 137.
  • Suzuki, R., et al. 2001. Br. J. Pharmacol. 132, 1615.
  • Boyle, D.L., et al. 2001. J. Pharmacol. Exp. Ther. 296, 495.
  • Kowaluk, E.A., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1165.
  • Jarvis, M.F., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1156.
  • CAS number 214697-26-4
  • ATP Competitive N
  • Form Yellow to orange solid
  • Hill Formula CHBrNO
  • Chemical formula CHBrNO
  • Hygroscopic Hygroscopic
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Adenosine Kinase 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 50.7 nM inhibiting adenosine kinase (AK) using intact IMR-32 cells and 1.7 nM in cell-free assays using rat brain cytosolic AK
  • Purity ≥ 90% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
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