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Merck - 118490-10MG - ATIC Dimerization Inhibitor - Calbiochem

  • MFR SKU: 118490-10MG
  • ITEM #: 13028423
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ITEM #: 13028423
ATIC Dimerization Inhibitor
, 10MG
This listing is for Each

Merck - 118490-10MG - ATIC Dimerization Inhibitor - Calbiochem

  • Item #: 13028423
  • MFR SKU: 118490-10MG
  • Overview A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (K i = 691 nM, K d = 240 nM). AITC is a bifunctional enzyme that catalyzes the last two steps of de novo purine biosynthesis. Increases the intracellular levels of AICAR leading to the activation of AMP-activated protein kinase (AMPK). Shown to reduce cell viability in a dose-dependent manner. Exhibits a longer half-life and sustained AMPK activation (~ 24 hours) compared to AICA-riboside (Cat. No. 123040 ).
  • Catalogue Number 118490
  • Brand Family Calbiochem®
  • Synonyms Ac-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor, AMPK Signaling Activator XI
  • References Spurr, I.B., et al. 2012. ChemBioChem 13, 1628.
  • Form White solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target ATIC i $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target K i " value=" Biological Information"
  • br> Primary Target K<sub>i</sub> 691 nM (K d
  • Purity ≥ 97% by HPLC
  • Cell permeable Y
  • Peptide Sequence Ac-Arg-Ph(4-NO2)-NEt2
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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