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Merck - 118500-10MG - ATM Kinase Inhibitor | CAS 587871-26-9 | Calbiochem | 10 MG

  • MFR SKU: 118500-10MG
  • ITEM #: 11572915
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ITEM #: 11572915
ATM Kinase Inhibitor, CAS 587871-26-9, is a cell-permeable, potent, ATP-competitive inhibitor of ATM Kinase (IC = 13 nM; K i = 2.2 nM).
This listing is for 10 mg Glass bottle

Merck - 118500-10MG - ATM Kinase Inhibitor | CAS 587871-26-9 | Calbiochem | 10 MG

  • Item #: 11572915
  • MFR SKU: 118500-10MG
  • Overview A cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC 50 = 13 nM; K i = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC 50 = 2.5 , 9.3 , 16.6 µ M for DNA-PK, mTOR, PI 3-K, respectively; IC 50 > 100 = µ M for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µ M. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents. A 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118502 ) in DMSO is also available.
  • Catalogue Number 118500
  • Brand Family Calbiochem®
  • Synonyms 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933
  • References Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
  • Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
  • Hickson, I., et al. 2004. Cancer Res. 64, 9152.
  • CAS number 587871-26-9
  • ATP Competitive Y
  • Form White solid
  • Hill Formula CHNOS
  • Chemical formula CHNOS
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target ATM Kinase 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 13 nM i $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target K i " value=" Biological Information"
  • br> Primary Target K<sub>i</sub> 2.2 nM for ATM kinase
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Shipped with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 1 month at -20° C.
  • Packaged under inert gas Packaged under inert gas

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