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Merck - 118501-5MG - ATM/ATR Kinase Inhibitor (CGK 733) | CAS 905973-89-9 | Calbiochem | 5MG

  • MFR SKU: 118501-5MG
  • ITEM #: 6281694
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ITEM #: 6281694
The ATM/ATR Kinase Inhibitor, also referenced under CAS 905973-89-9, controls the biological activity of ATM/ATR Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
This listing is for 5 mg Plastic ampoule

Merck - 118501-5MG - ATM/ATR Kinase Inhibitor (CGK 733) | CAS 905973-89-9 | Calbiochem | 5MG

  • Item #: 6281694
  • MFR SKU: 118501-5MG
  • Overview A cell-permeable thiourea compound that selectively inhibits the kinase activity of ATM and ATR (IC 50 = ~200 nM) without significant effect against other PIKK family members (PI 3-K, mTOR, and DNA-PK) or kinases that are known to phosphorylate p53 (ERK, CK1, Cdk2, JNK, PKC, CAK, Chk1, PKR, and p38). Shown to reverse senescence in human primary BJ and HMEC cells. Unlike LY 294002 (Cat. No. 440202 and 440204 ), this inhibitor does not interfere with cellular PI 3-K/PDK1/Akt signaling pathway.
  • Catalogue Number 118501
  • Brand Family Calbiochem®
  • Synonyms CGK 733
  • References Goldstein, M., et al. 2008. Toxicol. Appl. Pharmacol. in press .
  • Crescenzi, E., et al. 2008. Clin. Cancer Res. 14, 1877.
  • Cruet-Hennequart, S., et al. 2008. DNA Repair 7, 582.
  • Won, J., et al. 2006. Nat. Chem. Biol. 2, 369. (RETRACTED)
  • CAS number 905973-89-9
  • ATP Competitive N
  • Form Pale yellow solid
  • Hill Formula CHClFNOS
  • Chemical formula CHClFNOS
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target ATM/ATR 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> ~200 nM against ATM and ATR
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Irritant
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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