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Merck - 119140-10MG - Adenosine Receptor Agonist, NECA | CAS 35920-39-9 | Calbiochem | 10 MG

  • MFR SKU: 119140-10MG
  • ITEM #: 13028428
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ITEM #: 13028428
Adenosine Receptor Agonist
, NECA | CAS 35920-39-9 | Calbiochem | 10 MG
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Merck - 119140-10MG - Adenosine Receptor Agonist, NECA | CAS 35920-39-9 | Calbiochem | 10 MG

  • Item #: 13028428
  • MFR SKU: 119140-10MG
  • Overview A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (K i = 14 nM, 20 nM, 2.4 µ M and 6.2 nM for A 1 , A 2A , A 2B , A 3 , respectively). Increases intracellular cAMP production (EC 50 = 3.1 µ M in A 2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase.
  • Catalogue Number 119140
  • Brand Family Calbiochem®
  • Synonyms (2S, 3S, 4R, 5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3, 4-dihydroxytetrahydrofuran-2-carboxamide
  • References Forster, K., et al. 2006. Basic Res. Cardiol. 101, 319.
  • de Zwart, M., et al. 1998. Nucleosides Nucleotides. 17, 969.
  • Phillis, J. et al. 1986, Pharm. Biochem. Behavior. 24, 263
  • Durcan, M. J., et al. 1989. Pharmacol Biochem Behav. 32, 487.
  • Bacher, S., et al. 1982. Naunyn Schmiedebergs Arch Pharmacol. 329, 67.
  • Cusack, N., et al. 1981. Br J Pharm. 72, 443.
  • Londos, C., et al. 1980. Proc Natl Acad Sci. 77, 2551.
  • CAS number 35920-39-9
  • Form White solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100 i $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target K i " value=" Biological Information"
  • br> Primary Target K<sub>i</sub> 14 nM
  • Purity ≥ 98% by HPLC
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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