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Merck - 149101-1GM - 1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem

  • MFR SKU: 149101-1GM
  • ITEM #: 7010218
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ITEM #: 7010218
1-Aminocyclopropane-1-carboxylic Acid^ 1gm. ACPC. Crystalline solid. Agonist for glycine modulatory site of N-methyl-D-aspartate (NMDA) receptor complex. Mimics effects of glycine on NMDA receptor ion channel & blocks 3H-glycine binding to rat forebrain membrane. RTECS GZ1110000, CAS 22059-21-8.
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Merck - 149101-1GM - 1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem

  • Item #: 7010218
  • MFR SKU: 149101-1GM
  • Overview An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks 3 H-glycine binding to rat forebrain membrane (IC 50 = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC 50 = 131 µ M) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.
  • Catalogue Number 149101
  • Brand Family Calbiochem®
  • Synonyms ACPC
  • References Viu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
  • Zapata, A., et al. 1996. NeuroReport 7, 397.
  • Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
  • Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
  • Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
  • Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
  • Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.
  • CAS number 22059-21-8
  • ATP Competitive N
  • Form Crystalline solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Application 1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8, is an agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.
  • Primary Target Glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 38 nM in blocking 3H-glycine binding to rat forebrain membrane; 131 µ M in blocking NMDA-induced release of arachidonic acid; 131 µ M in cerebellar granule cells
  • Purity ≥ 98% by TLC
  • Cell permeable N
  • RTECS GZ1110000
  • R Phrase R: 36/37/38
  • Irritating to eyes, respiratory system and skin.
  • S Phrase S: 26-36
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Irritant
  • Storage +15° C to +30° C
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 1 month at -20° C.

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