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Merck - 178270-500UG - Apamin, Bee Venom | CAS 24345-16-2 | Calbiochem | 500UG

  • MFR SKU: 178270-500UG
  • ITEM #: 7009903
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ITEM #: 7009903
Apamin, Bee Venom^ ( H-Cys1-Asn-Cys3-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys11-Ala-Arg-Arg-Cys15-Gln-Gln-His-NH2 (disulfide bonds: 1 -> 11; 3 -> 15)). Lyophilized solid. PROTECT FROM MOISTURE. Polypeptide neurotoxin known to pass through the blood-brain barrier.
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Merck - 178270-500UG - Apamin, Bee Venom | CAS 24345-16-2 | Calbiochem | 500UG

  • Item #: 7009903
  • MFR SKU: 178270-500UG
  • Overview Polypeptide neurotoxin known to pass through the blood-brain barrier. Blocks the AHP-type Ca 2+ -activated K + channel; does not block the TEA and voltage-sensitive Ca 2+ -activated K + channel. Reported to induce neurodegeneration of Purkinje cells in rat brain. Known to induce the secretion of prolactin in a dose-dependent manner.
  • Catalogue Number 178270
  • Brand Family Calbiochem®
  • Synonyms CNCKAPETALCARRCQQH-NH
  • References Mourre, C., et al. 1997. Brain Res. 778, 405.
  • Silva, E.G., et al. 1994. Br. J. Pharmacol. 113, 1022.
  • Wang, X., et al. 1994. Brain Res. 662, 83.
  • CAS number 24345-16-2
  • ATP Competitive N
  • Form White solid with dark tan cast
  • Hill Formula CHNOS
  • Chemical formula CHNOS
  • Hygroscopic Hygroscopic
  • Reversible N
  • Quality Level MQ100
  • Primary Target AHP-type Ca2+-activated K+ channel
  • Purity ≥ 98% by HPLC
  • Cell permeable N
  • Peptide Sequence H-Cys¹-Asn-Cys³-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys¹¹-Ala-Arg-Arg-Cys¹-Gln-Gln-His-NH (disulfide bonds: 1 → 11; 3 → 15)
  • RTECS CD6899900
  • R Phrase R: 20/21/22
  • Harmful by inhalation, in contact with skin and if swallowed.
  • S Phrase S: 36
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Harmful
  • Storage -20° C
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Acetic acid stock solutions are stable for up to 3 days at -20° C.

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