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Merck - 178385-1GM - Apocynin | CAS 498-02-2 | Calbiochem | 1GM

  • MFR SKU: 178385-1GM
  • ITEM #: 6131403
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ITEM #: 6131403
Apocynin^ 1gm. Acetovanillone, 4-Hydroxy-3-methoxyacetophenone. Yellow solid. Protect from light. Packaged under inert gas. Cell-permeable, anti-inflammatory phenolic compoundacting as potent and selective inhibitor of NADPH oxidase. Purity:>=98% by GC. RTECS AM8800000, CAS 498-02-2.
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Merck - 178385-1GM - Apocynin | CAS 498-02-2 | Calbiochem | 1GM

  • Item #: 6131403
  • MFR SKU: 178385-1GM
  • Overview A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase. Shown to block peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through activation of AP-1. Also reported to prevent phagocytosis of myelin by macrophages (10 mM).
  • Catalogue Number 178385
  • Brand Family Calbiochem®
  • Synonyms 4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V
  • References Abid, M.R., et al. 2000. FEBS Lett. 486, 252.
  • Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932.
  • Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235.
  • Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776.
  • van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67.
  • Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.
  • CAS number 498-02-2
  • ATP Competitive N
  • Form White to off-white powder
  • Hill Formula CHO
  • Chemical formula CHO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target NADPH oxidase
  • Purity ≥ 98% by GC
  • Cell permeable Y
  • RTECS AM8800000
  • Ship Code Ambient Temperature Only
  • Toxicity Irritant
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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