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Merck - 178493-10MG - Apoptosis Activator III, Embelin (XIAP inhibitor) | CAS 550-24-3 | Calbiochem | 10MG

  • MFR SKU: 178493-10MG
  • ITEM #: 6281295
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ITEM #: 6281295
The Apoptosis Activator III, Embelin, also referenced under CAS 550-24-3, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
This listing is for 10 mg Plastic ampoule

Merck - 178493-10MG - Apoptosis Activator III, Embelin (XIAP inhibitor) | CAS 550-24-3 | Calbiochem | 10MG

  • Item #: 6281295
  • MFR SKU: 178493-10MG
  • Overview A cell-permeable benzoquinone compound that exhibits antitumor properties. Specifically antagonizes XIAP (X-linked inhibitor of apoptosis)-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC 50 = 4.1 µ M in a competitive binding assay with Smac peptide). Selectively induces caspase-9-mediated apoptosis in prostate cancer cells with high levels of XIAP (IC 50 = 3.7 and 5.7 µ M for PC-3 and LnCap, respectively), while exhibiting much less effect towards cells with low level XIAP (IC 50 = 19.3 and 20.1 µ M for WI-38 and PrEC, respectively). Also shown to sensitize XIAP overexpressing Jurkat cells to Etoposide -induced apoptosis. A non-competitive PCAF (p300/CBP associated factor)-specific lysine acetyltransferase (KAT) inhibitor (IC 50 = 7.2 µ M).
  • Catalogue Number 178493
  • Brand Family Calbiochem®
  • Synonyms Embelin, Embelia ribes , XIAP inhibitor, Embelin, 2, 5-Dihydroxy-3-undecyl-1, 4-benzoquinone
  • References Modak, R., et al. 2013. ACS Chem. Biol. 8, In press.
  • Nikolovska-Coleska, Z., et al. 2004. J. Med. Chem. 47, 2430.
  • CAS number 550-24-3
  • ATP Competitive N
  • Form Orange solid
  • Hill Formula CHO
  • Chemical formula CHO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target BIR3 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 4.1 µ M in antagonizing XIAP (X-linked inhibitor of apoptosis)-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 in a competitive binding assay with Smac peptide
  • Purity Single spot by TLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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