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Merck - 178497-10MG - Apoptosis Activator VII, Apoptozole | CAS 1054543-47-3 | Calbiochem | 10 MG

  • MFR SKU: 178497-10MG
  • ITEM #: 6294803
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ITEM #: 6294803
The Apoptosis Activator VII, Apoptozole, also referenced under CAS 1054543-47-3, modulates Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
This listing is for 10 mg Plastic ampoule

Merck - 178497-10MG - Apoptosis Activator VII, Apoptozole | CAS 1054543-47-3 | Calbiochem | 10 MG

  • Item #: 6294803
  • MFR SKU: 178497-10MG
  • Overview A cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 ( K d = 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC 50 = 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 hours drug treatment (1 µ M).
  • Catalogue Number 178497
  • Brand Family Calbiochem®
  • Synonyms N-(4-Carboxamidobenzyl)-2-(3, 5- bis -trifluoromethyl)-4, 5- bis -(4-methoxyphenyl)-imidazole, Hsp70 Inhibitor III
  • References Cho, H.J., et al. 2012. J. Am. Chem. Soc. 133, 20267.
  • Williams, D.R., et al. 2008. Angew. Chem. Int. Ed. 47, 7466.
  • CAS number 1054543-47-3
  • Form White solid
  • Hill Formula CHFNO
  • Chemical formula CHFNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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