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Merck - 17-10044 - 17-10044, ChIPAb+ CTCF - ChIP Validated Antibody and Primer Set clone 1.2.1.5.4, from mouse

  • MFR SKU: 17-10044
  • ITEM #: 11574353
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ITEM #: 11574353
CTCF, also known as CCCTC-binding factor, contains 11 zinc finger (ZF) binding domains that allow it to bind different DNA target sequences and proteins. This multifunctional protein can act as a transcriptional activator or repressor. As a transcriptional repressor, CTCF, binds to promoters of vertebrate c-myc gene. It also binds to the PLK and PIM1 promoters. CTCF may prevent the access of transcriptional activators to enhancers. CTCF also acts as a transcriptional activator of APP. It is involved...
ITEM #: 11574353
CTCF, also known as CCCTC-binding factor, contains 11 zinc finger (ZF) binding domains that allow it to bind different DNA target sequences and proteins. This multifunctional protein can act as a transcriptional activator or repressor. As a transcriptional repressor, CTCF, binds to promoters of vertebrate c-myc gene. It also binds to the PLK and PIM1 promoters. CTCF may prevent the access of transcriptional activators to enhancers. CTCF also acts as a transcriptional activator of APP. It is involved in different aspects of gene regulation including promoter activation or repression, hormone-responsive gene silencing, methylation-dependent chromatin insulation, and genomic imprinting. Mutations of CTCF in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms tumors, suggesting a role for CTCF may as a tumor suppressor.
Synonyms: 11 zinc finger transcriptional repressor, 11-zinc finger protein, CCCTC-binding factor, CCCTC-binding factor (zinc finger protein), CTCFL paralog, transcriptional repressor CTCF
Application: The ChIPAb+ CTCF set includes the CTCF antibody, a negative control antibody (normal mouse IgG) & qPCR primers which amplify a 165 bp region of human H19 internal control region.
: UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
17-10044, ChIPAb+ CTCF - ChIP Validated Antibody and Primer Set clone 1.2.1.5.4, from mouse
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Merck - 17-10044 - 17-10044, ChIPAb+ CTCF - ChIP Validated Antibody and Primer Set clone 1.2.1.5.4, from mouse

  • Item #: 11574353
  • MFR SKU: 17-10044

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