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Merck - 182690-10MG - AhR Agonist V, VAF347 | Calbiochem | 10 MG

  • MFR SKU: 182690-10MG
  • ITEM #: 11574618
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$282.50
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ITEM #: 11574618
The AhR Agonist V, VAF347 controls the biological activity of AhR. This small molecule/inhibitor is primarily used for Biochemicals applications.
This listing is for 10 mg Glass bottle

Merck - 182690-10MG - AhR Agonist V, VAF347 | Calbiochem | 10 MG

  • Item #: 11574618
  • MFR SKU: 182690-10MG
  • Overview A cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC 50 of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
  • Catalogue Number 182690
  • Brand Family Calbiochem®
  • Synonyms (4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine
  • References Platzer, B., et al. 2009. J. Immunol. 183, 66.
  • Hauben, E., et al. 2008. Blood 118, 1214.
  • Lawrence, B.P., et al. 2008. Blood 112, 1158.
  • Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.
  • Form White solid
  • Hill Formula CHClFN
  • Chemical formula CHClFN
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 99% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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