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Merck - 189510-5MG - Autotaxin Inhibitor I, S32826 | CAS 1103672-43-0 | Calbiochem | 5MG

  • MFR SKU: 189510-5MG
  • ITEM #: 11592051
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ITEM #: 11592051
The Autotaxin Inhibitor I, S32826, also referenced under CAS 1103672-43-0, controls the biological activity of Autotaxin.
This listing is for 5 mg Glass bottle

Merck - 189510-5MG - Autotaxin Inhibitor I, S32826 | CAS 1103672-43-0 | Calbiochem | 5MG

  • Item #: 11592051
  • MFR SKU: 189510-5MG
  • Overview A phosphonate compound that potently inhibits both the phosphodiesterase (IC 50 = 9 nM in pNppp assay using ATX β) and the lysoPLD (IC 50 = 5.6 nM and 47 nM, by enzyme-linked fluorescence detection or autoradiography by TLC, respectively, using ATX β) activities of ATX α/β/γ, while exhibiting much reduced (IC 50 ~ 6 µ M and 15 µ M against Src and PTP-1B, respectively) or little activity toward 29 other receptors and enzymes. Shown to block LPA release from murine 3T3F422A adipocytes (IC 50 = 90 nM) in vitro and from excised human and rat adipose tissues (by ~70% inhibition at 0.2 and 1 µ M, respectively) in cultures ex vivo . The in vivo applicability of S32826 is limited by its low epithelial permeability and other poor pharmacokinetic properties. CTAB (Cat. No. 219374 ) is reported to counteract the inhibitory activity of S32826, 2-methyl-2, 4-pentanediol can be used instead to stabilize purified enzyme in solution during S32826 inhibition assays.
  • Catalogue Number 189510
  • Brand Family Calbiochem®
  • Synonyms ATX Inhibitor I, (4-(Tetradecanoylamino)benzyl)phosphonic acid disodium, dihydrate
  • References Boutin, J.A., and Ferry, G. 2009. Cell Mol. Life Sci. 66, 3009.
  • Samadi, N., et al. 2009. Oncogene 28, 1028.
  • Ferry, G., et al. 2008. J. Pharm. Exp. Ther. 327, 809.
  • CAS number 1103672-43-0
  • Form White powder
  • Hill Formula CHNOPNa • 2HO
  • Chemical formula CHNOPNa • 2HO
  • Hygroscopic Hygroscopic
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 97% by HPLC
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Regulatory Review
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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