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Merck - 189511-10MG - Autotaxin Inhibitor II, HA130 - Calbiochem

  • MFR SKU: 189511-10MG
  • ITEM #: 11574632
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ITEM #: 11574632
Autotaxin Inhibitor II, HA130
, 10MG
This listing is for Each

Merck - 189511-10MG - Autotaxin Inhibitor II, HA130 - Calbiochem

  • Item #: 11574632
  • MFR SKU: 189511-10MG
  • Overview A thiazolidinedione that is designed to target the ATX active site thr210 with a boronic moiety and shown to potently inhibit ATX lysoPLD activity (IC 50 ~28 nM using recombinant human ATX or human plasma) in a reversible manner with a mixed-type Lineweaver-Burk kinetics. Reported to exhibit low cytotoxicity (TD 50 = 83, 105, and 2056 µ M in HEK293T, A2058, and HepG2 cultures) and no activity toward NPP1, PDE, AP, or proteasomal chymotryptic/tryptic/caspase-like activities even at concentrations as high as 10 µ M. Although HA130 quickly and effectively reduces circulating LPA level when injected in mice (463 µg/kg, i.v.) in vivo , the effect appears short-lived as is the case with S32826 (Cat. No. 189510 ).
  • Catalogue Number 189511
  • Brand Family Calbiochem®
  • Synonyms ATX Inhibitor II, (Z)-3-((4-((3-(4-Fluorobenzyl)-2, 4-dioxo-1, 3-thiazolan-5-yliden)-methyl)phenoxy)methyl)benzeneboronic acid
  • References Albers, H.M.H.G. et al. 2010. J. Med. Chem. 53, 4958.
  • Albers, H.M.H.G. et al. 2010. Proc. Natl. Acad. Sci. USA 107, 7257.
  • Form Off-white solid
  • Hill Formula CHBFNOS
  • Chemical formula CHBFNOS
  • Hygroscopic Hygroscopic
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 97% by HPLC
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Regulatory Review
  • Storage -20° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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