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Merck - 189512-10MG - Autotaxin Inhibitor III, PF-8380 (Atx Inhibitor) | Calbiochem | 10 MG

  • MFR SKU: 189512-10MG
  • ITEM #: 11574633
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ITEM #: 11574633
The Autotaxin Inhibitor III, PF-8380, also referenced under CAS 1144035-53-9, controls the biological activity of Autotaxin. This small molecule/inhibitor is primarily used for Membrane applications.
This listing is for 10 mg Glass bottle

Merck - 189512-10MG - Autotaxin Inhibitor III, PF-8380 (Atx Inhibitor) | Calbiochem | 10 MG

  • Item #: 11574633
  • MFR SKU: 189512-10MG
  • Overview An orally bioavailable piperazinylbenzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC 50 = 2.8 and 1.7 nM for recombinant human enzyme-β isoform employing FS-3 and LPC (lysophosphatidylcholine) as substrates, respectively; 1.16 and 1.15 nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101 nM for human whole blood}. Displays desirable pharmacokinetics properties and efficiently blocks inflammation-induced LPA (lysophosphatidic acid) production both in plasma and at the site of inflammation by 95% in rat adjuvant-induced arthritis model (30 mg/kg, p.o.).
  • Catalogue Number 189512
  • Brand Family Calbiochem®
  • Synonyms 6-(3-(Piperazin-1-yl)propanoyl)-benzo[d]oxazol-2(3H)-one, Atx Inhibitor III, PF-8380
  • References Gierse, J., et al. 2010. J. Pharmacol. Exp. Ther. 334, 310.
  • CAS number 1144035-53-9
  • Form Tan powder
  • Hill Formula CHClNO
  • Chemical formula CHClNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC
  • Ship Code Dry Ice Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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