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Merck - 190080-5MG - AY 9944 (AY9944) | CAS 366-93-8 | Calbiochem | 5MG

  • MFR SKU: 190080-5MG
  • ITEM #: 6281421
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ITEM #: 6281421
A cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification.
This listing is for 5 mg Glass bottle

Merck - 190080-5MG - AY 9944 (AY9944) | CAS 366-93-8 | Calbiochem | 5MG

  • Item #: 6281421
  • MFR SKU: 190080-5MG
  • Overview A cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification. Specifically blocks 7-dehydrocholesterol reductase (Δ 7 -sterol reductase) activity with IC 50 = 13 nM. Important tool in Sonic Hedgehog signaling and teratogenicity studies. Also reported to induce a rapid and irreversible reduction in Acidic-Sphingomyelinase activity in fibroblasts.
  • Catalogue Number 190080
  • Brand Family Calbiochem®
  • Synonyms trans -1, 4- bis (2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV
  • References Gofflot, F., et al. 2001. Dev. Dyn. 220, 99.
  • Cooper, M.K., et al. 1998. Science 280, 1603.
  • Incardona, J.P., et al. 1998. Development 125, 3553.
  • Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 1899.
  • Yoshida, Y. 1985. J. Biochem. 98, 1669.
  • Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.
  • CAS number 366-93-8
  • ATP Competitive N
  • Form White solid
  • Hill Formula CHClN • 2HCl
  • Chemical formula CHClN • 2HCl
  • Hygroscopic Hygroscopic
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target 7-dehydrocholesterol reductase (δ 7-sterol reductase) 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 13 nM in blocking 7-dehydrocholesterol reductase (δ 7-sterol reductase) activity
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • RTECS GU7025000
  • Ship Code Ambient Temperature Only
  • Toxicity Harmful & Carcinogenic / Teratogenic
  • Storage +2° C to +8° C
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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