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Merck - 196000-1SET - Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem

  • MFR SKU: 196000-1SET
  • ITEM #: 11574654
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ITEM #: 11574654
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This listing is for 1 set Glass bottle

Merck - 196000-1SET - Bafilomycin A1, <i>Streptomyces griseus</i> - CAS 88899-55-2 - Calbiochem

  • Item #: 11574654
  • MFR SKU: 196000-1SET
  • Overview A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H + -ATPase (V-type; K i = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution™ format with a purity of ≥ 97% by HPLC in 90% DMSO is also available (Cat. No. 508409 ).
  • Note: 1 set = 3 x 10 µg
  • Catalogue Number 196000
  • Brand Family Calbiochem®
  • References Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
  • Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
  • Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
  • Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
  • Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
  • Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
  • Drose, S., et al. 1993. Biochemistry 32, 3902.
  • Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
  • Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.
  • CAS number 88899-55-2
  • Form White solid
  • Hill Formula CHO
  • Chemical formula CHO
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target vacuolar type H + ATPase 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 500 pM
  • Purity ≥ 90% by HPLC
  • R Phrase R: 36/37/38
  • Irritating to eyes, respiratory system and skin.
  • S Phrase S: 22-26-36
  • Do not breathe dust.
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Carcinogenic / Teratogenic
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). DMSO stock solutions are stable for up to 1 year at -20° C.

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