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Merck - 196322-10MG - Baicalein | CAS 491-67-8 | Calbiochem | 10MG

  • MFR SKU: 196322-10MG
  • ITEM #: 3441209
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ITEM #: 3441209
Baicalein^ (5, 6, 7-Trihydroxyflavone). Flavone that inhibits the activity of 12-lipoxygenase (IC50=120nM) and reverse transcriptase. Purity: >=98% by TLC. Soluble in acetone and DMSO. CAS: 491-67-8. FW: 270.2. Yellow solid, 10mg.
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Merck - 196322-10MG - Baicalein | CAS 491-67-8 | Calbiochem | 10MG

  • Item #: 3441209
  • MFR SKU: 196322-10MG
  • Overview A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC 50 = 120 nM) and reverse transcriptase. Protects cortical neurons from β-amyloid induced toxicity. Reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Also inhibits cellular Ca 2+ uptake and mobilization, and adjuvant-induced arthritis. Reported to inhibit microsomal lipid peroxidation by forming an iron-baicalein complex. Inhibits topoisomerase II and induces cell death in hepatocellular carcinoma cell lines. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated protein kinase C.
  • Catalogue Number 196322
  • Brand Family Calbiochem®
  • Synonyms 5, 6, 7-Trihydroxyflavone
  • References Leabeau, A., et al. 2001. Neuroreport 12, 2199.
  • Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
  • Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
  • Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
  • Butenko, I.G., et al. 1993. Agents Actions 39, C49.
  • Abe, K., et al. 1990. Chem. Pharm. Bull. 38, 209.
  • Kimura, Y., et al. 1987. Biochim. Biophys. Acta 922, 278.
  • Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun. 105, 1090.
  • CAS number 491-67-8
  • ATP Competitive N
  • Form Yellow solid
  • Hill Formula CHO
  • Chemical formula CHO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target 12-lipoxygenase 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 120 nM against 12-lipoxygenase
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • R Phrase R: 36/37/38
  • Irritating to eyes, respiratory system and skin.
  • S Phrase S: 26-36
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • Ship Code Blue Ice Only
  • Toxicity Irritant
  • Storage -20° C
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 1 month at -20° C.

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