Image is an illustration, may not reflect the exact product sold.


Other products by Merck

Merck - 217721-2MG - InSolution Cdk1 Inhibitor IV, RO-3306 | Calbiochem | 2 MG

  • MFR SKU: 217721-2MG
  • ITEM #: 11574784
  • 0 Reviews / 0 Questions
$296.00
Stock Status: SHIPS SOON (reserve your unit today)
Average lead time for this brand: 2-3 weeks. Specific products may vary.

ITEM #: 11574784
The InSolution™ Cdk1 Inhibitor IV, RO-3306 controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
This listing is for 2 mg Glass bottle

Merck - 217721-2MG - InSolution Cdk1 Inhibitor IV, RO-3306 | Calbiochem | 2 MG

  • Item #: 11574784
  • MFR SKU: 217721-2MG
  • Overview A cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (K i = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (K i = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (K i =2 µ M). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. The solid form of this compound (Cat. No. 217699 ) is also available.
  • Catalogue Number 217721
  • Brand Family Calbiochem®
  • Synonyms 5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one, 5-(6-Quinolinylmethylene)-2-((2-thienylmethyl)amino)-4(5H)-thiazolone
  • References Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660.
  • Form Liquid
  • Formulation A 10 mM (2 mg/569 µ L) solution of Cdk1 Inhibitor IV, RO-3306 ( Cat. No. 217699 ) in DMSO.
  • Hill Formula CHNOS
  • Hygroscopic Hygroscopic
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Cdk1/B1 and Cdk1/A i $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target K i " value=" Biological Information"
  • br> Primary Target K<sub>i</sub> 35 nM and 110 nM for Cdk1/B1 and Cdk1/A,
  • Secondary target Cdk2/E, PKCδ, and SGK
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • R Phrase R: 36/38
  • Irritating to eyes and skin.
  • S Phrase S: 26-36
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • Ship Code Dry Ice Only
  • Toxicity Irritant
  • Storage ≤ -70° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Avoid freeze/thaw Avoid freeze/thaw
  • Do not freeze Ok to freeze
  • Special Instructions Following initial thaw, aliquot and freeze (-70° C). Aliquots are stable for up to 6 months at -70° C.
  • Packaged under inert gas Packaged under inert gas

There are no questions about this product yet. Be the first to ask a question.

0 out of 5 stars
5 Star
0 %
4 Star
0 %
3 Star
0 %
2 Star
0 %
1 Star
0 %

Review this product

Tell us about your personal experience

Recently Viewed Items