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Merck - 219330-10MG - beta-Catenin/Tcf Inhibitor, FH535 | CAS 108409-83-2 | Calbiochem | 10 MG

  • MFR SKU: 219330-10MG
  • ITEM #: 4150394
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ITEM #: 4150394
The β-Catenin/Tcf Inhibitor, FH535, also referenced under CAS 108409-83-2, controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Cell Signaling applications.
This listing is for 10 mg Plastic ampoule

Merck - 219330-10MG - beta-Catenin/Tcf Inhibitor, FH535 | CAS 108409-83-2 | Calbiochem | 10 MG

  • Item #: 4150394
  • MFR SKU: 219330-10MG
  • Overview A cell-permeable sulfonamide compound that acts as a dual pathway inhibitor against Wnt/β-catenin (≥ 80% inhibition at 15 µ M in β-catenin/Tcf-dependent cellular reporter assays) and PPARγ/δ (≥ 30% inhibition at 0.5 µ M in PPRE cellular reporter assays) signalings. Although both FH535 and the structurally similar PPARγ-selective inhibitor GW9662 (Cat. No. 370700 ) inhibit coactivator/PPAR binding, only FH535 blocks β-catenin/PPARγ interaction and the antagonistic activity of FH535 does not involve the covalent modification of or non-covalent interaction with the PPAR ligand-binding site cystein residue that is crucial for GW9662 action.
  • Catalogue Number 219330
  • Brand Family Calbiochem®
  • Synonyms N-(2-Methyl-4-nitro)-2, 4-dichlorosulfonamide, Wnt Pathway Inhibitor IX
  • References Handeli, S., and Simon, J.A. 2008. Mol. Cancer Ther. 7, 521.
  • CAS number 108409-83-2
  • Form Yellow solid
  • Hill Formula CHClNOS
  • Chemical formula CHClNOS
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 99% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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