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Merck - 219331-10MG - beta-Catenin/Tcf Inhibitor II, PKF118-310 (b-catenin/Tcf) | Calbiochem | 10MG

  • MFR SKU: 219331-10MG
  • ITEM #: 11574796
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$275.00
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ITEM #: 11574796
The β-Catenin/Tcf Inhibitor II, PKF118-310 controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Cancer applications.
This listing is for 10 mg Glass bottle

Merck - 219331-10MG - beta-Catenin/Tcf Inhibitor II, PKF118-310 (b-catenin/Tcf) | Calbiochem | 10MG

  • Item #: 11574796
  • MFR SKU: 219331-10MG
  • Overview A synthetic cell-permeable actinobacteria pyrimidotriazine-dione that selectively disrupts β-catenin-Tcf4 interaction (IC 50 = 0.8 µ M in cell-free binding assays) and inhibits β-catenin-regulated cellular transcription activity (IC 50 = 0.3 µ M in HCT116-based reporter assays). PKF118-310 is demonstrated to reverse β- catenin , but not siamois , mRNA-induced ventral body axis formation in Xenopus embryos, while direct tumor site injection (1 mg/kg/0.5 wk) in HepG2 xenograph mice is shown to increase the number of apoptotic cells and decrease the expression of β-catenin target genes (cyclin D1, c-Myc, survivin) in the tumor mass, resulting in an effective tumor growth retardation (by ~60% after a 4-wk treatment period) in vivo .
  • Catalogue Number 219331
  • Brand Family Calbiochem®
  • Synonyms 1, 6-Dimethylpyrimido[5, 6-e][1, 2, 4]triazine-5, 7-dione, Wnt Pathway Inhibitor X
  • References Wei, W., et al. 2010. Int. J. Cancer 126, 2426.
  • Lepourcelet, M., et al. 2004. Cancer Cell 5, 91.
  • Form Dark yellow solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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