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Merck - 219334-10MG - b-Catenin/Tcf Inhibitor V, BC21 (beta-Catenin) | CAS 691005-38-6 | Calbiochem | 10 MG

  • MFR SKU: 219334-10MG
  • ITEM #: 11574798
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ITEM #: 11574798
The β-Catenin/Tcf Inhibitor V, BC21, also referenced under CAS 691005-38-6, controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Biochemicals applications.
This listing is for 10 mg Glass bottle

Merck - 219334-10MG - b-Catenin/Tcf Inhibitor V, BC21 (beta-Catenin) | CAS 691005-38-6 | Calbiochem | 10 MG

  • Item #: 11574798
  • MFR SKU: 219334-10MG
  • Overview A cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC 50 = 5.0 µ M), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µ M), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µ M).
  • Catalogue Number 219334
  • Brand Family Calbiochem®
  • Synonyms Copper, di-µ-chlorobis[1-[(1-piperidinyl-κ N)methyl]-2-naphthalenolato-κ O]di-(9Cl), Wnt Pathway Inhibitor XV
  • References Tian, W., et al. 2012. Biochemistry 51, 724.
  • Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
  • Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.
  • CAS number 691005-38-6
  • Form Dark brown solid
  • Hill Formula CHClCuNO
  • Chemical formula CHClCuNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 95% by Elemental Analysis
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution aliquot, freeze (≥-70° C). Stock solutions are stable for up to 12 months at ≥-70° C.
  • Packaged under inert gas Packaged under inert gas

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