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Merck - 219493-10MG - Ceramide Kinase Inhibitor II, NVP-231 | Calbiochem | 10MG

  • MFR SKU: 219493-10MG
  • ITEM #: 11574806
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$380.00
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ITEM #: 11574806
The Ceramide Kinase Inhibitor II, NVP-231 controls the biological activity of Ceramide Kinase. This small molecule/inhibitor is primarily used for Membrane applications.
This listing is for 10 mg Glass bottle

Merck - 219493-10MG - Ceramide Kinase Inhibitor II, NVP-231 | Calbiochem | 10MG

  • Item #: 11574806
  • MFR SKU: 219493-10MG
  • Overview A cell-permeable benzothiazole compound that potently inhibits Cer (ceramide) phosphorylation by CerK (Cer Kinase) in a reversible and Cer-, but not ATP-, competitive manner (IC 50 = 12 nM; K i = 7.4 nM) with excellent selectivity over hDAGKα (IC 50 = 5 µ M) and little or no activity against eight other lipid metabolizing enzymes and kinases (IC 50 ≥ 10 µ M) in cell-free enzymatic assays. When applied to live cells in cultures, NVP-231 effectively prevents the binding of Cer to CerK, making cellular Cer more available to other Cer metabolizing enzymes and resulting in an increased GlcCer (glucosylceramide) and SM (sphingomyelin) production in addition to the expected decrease of Cer phosphorylation.
  • Catalogue Number 219493
  • Brand Family Calbiochem®
  • Synonyms Adamantane-1-carboxylic acid-(2-benzoylamino-benzothiazol-6-yl)-amide, CerK Inhibitor II, NVP-231
  • References Graf, C., et al. 2008. Mol. Pharmacol. 74, 925.
  • Form Tan solid
  • Hill Formula CHNOS
  • Chemical formula CHNOS
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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