Image is an illustration, may not reflect the exact product sold.


Other products by Merck

Merck - 219672-10MG - CFTR Inhibitor III, OXO-172 | Calbiochem | 10MG

  • MFR SKU: 219672-10MG
  • ITEM #: 11574815
  • 0 Reviews / 0 Questions
$234.50
Stock Status: SHIPS SOON (reserve your unit today)
Average lead time for this brand: 2-3 weeks. Specific products may vary.

ITEM #: 11574815
The CFTR Inhibitor III, OXO-172 controls the biological activity of CFTR. This small molecule/inhibitor is primarily used for Biochemicals applications.
This listing is for 10 mg Plastic ampoule

Merck - 219672-10MG - CFTR Inhibitor III, OXO-172 | Calbiochem | 10MG

  • Item #: 11574815
  • MFR SKU: 219672-10MG
  • Overview A cell-permeable CFTR inh -172 (Cat. No. 219670 ) 2-oxo analog that exhibits ~25-fold higher aqueous solubility than the 2-thioxo CFTR inh -172 (420 µ M vs. 17 µ M, respectively, in PBS with 2% DMSO at 25 ° C) and great potency, albeit slightly weaker than that of CFTR inh -172, in inhibiting CFTR-mediated apical membrane chloride current upon 20 µ M Forskolin (Cat. No. 344270 ) stimulation in CFTR-expressing FRT cells (IC 50 = 1.4 µ M vs. 0.38 µ M with CFTR inh -172) with practically no cytotoxicity (91% of no-drug control FRT in viability assay; 48 h at 50 µ M).
  • Catalogue Number 219672
  • Brand Family Calbiochem®
  • Synonyms 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-4-thiazolidinone, OXO-172
  • References Sonawane, N.D., and Verkman, A.S. 2008. Bioorg. Med. Chem. 16, 8187.
  • Form Off-white solid
  • Hill Formula CHFNOS
  • Chemical formula CHFNOS
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC and NMR
  • R Phrase R: 36/37/38-43
  • Irritating to eyes, respiratory system and skin.
  • May cause sensitization by skin contact.
  • S Phrase S: 26-36/37-45-61
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing and gloves.
  • In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
  • Avoid release to the environment. Refer to special instructions/safety data sheet.
  • Ship Code Ambient Temperature Only
  • Toxicity Irritant
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

There are no questions about this product yet. Be the first to ask a question.

0 out of 5 stars
5 Star
0 %
4 Star
0 %
3 Star
0 %
2 Star
0 %
1 Star
0 %

Review this product

Tell us about your personal experience

Recently Viewed Items