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Merck - 219677-10MG - CFTR Inhibitor IV, PPQ-102 | CAS 931706-15-9 | Calbiochem | 10 MG

  • MFR SKU: 219677-10MG
  • ITEM #: 6295724
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ITEM #: 6295724
CFTR Inhibitor IV, PPQ-102, CAS 931706-15-9, is a cell-permeable inhibitor of CFTR-mediated chloride current in a reversible and voltage-independent manner.
This listing is for 10 mg Glass bottle

Merck - 219677-10MG - CFTR Inhibitor IV, PPQ-102 | CAS 931706-15-9 | Calbiochem | 10 MG

  • Item #: 6295724
  • MFR SKU: 219677-10MG
  • Overview A cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270 ) and IBMX (Cat. No. 410957 ) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 µ M PPQ-102). PPQ-102 at 5 µ M is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818 ) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture.
  • Catalogue Number 219677
  • Brand Family Calbiochem®
  • Synonyms 7, 9-Dimethyl-11-phenyl-6-(5-methylfuran-2-yl)-5, 6-dihydro-pyrimido-[4, 5-3, 4]pyrrolo[1, 2-a]quinoxaline-8, 10-(7H, 9H)-dione, Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV
  • References Tradtrantip, L., et al. 2009. J. Med. Chem. 52, 6447.
  • CAS number 931706-15-9
  • Form White crystalline solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Structure formula Image
  • Quality Level MQ100
  • Application CFTR Inhibitor IV, PPQ-102, CAS 931706-15-9, is a cell-permeable inhibitor of CFTR-mediated chloride current in a reversible and voltage-independent manner.
  • Purity ≥ 95% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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