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Merck - 236005-5MG - COX-1 Inhibitor, FR122047 (COX1) | CAS 130717-51-0 | Calbiochem | 5MG

  • MFR SKU: 236005-5MG
  • ITEM #: 6281330
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ITEM #: 6281330
The COX-1 Inhibitor, FR122047, also referenced under CAS 130717-51-0, controls the biological activity of COX-1. This small molecule/inhibitor is primarily used for Cell Signaling applications.
This listing is for 5 mg Plastic ampoule

Merck - 236005-5MG - COX-1 Inhibitor, FR122047 (COX1) | CAS 130717-51-0 | Calbiochem | 5MG

  • Item #: 6281330
  • MFR SKU: 236005-5MG
  • Overview A cell-permeable trisubstituted thiazole compound that acts as a potent and selective inhibitor of COX-1 (IC 50 = 28 nM and 65 µ M for human recombinant COX-1 and COX-2, respectively). Displays ~2, 300 fold greater selectivity towards inhibition of COX-1 over COX-2. Reported to be orally active and display analgesic, anti-platelet and anti-inflammatory properties.
  • Catalogue Number 236005
  • Brand Family Calbiochem®
  • Synonyms FR 122047, 1-[(4, 5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride, 4, 5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride
  • References Ochi, T., and Goto, T. 2002. Br. J. Pharmacol. 135, 782.
  • Ochi, T., et al. 2000. Eur. J. Pharmacol. 391, 49.
  • Tanaka, A., et al. 1994. J. Med. Chem. 37, 1189.
  • Dohi, M., et al. 1993. Eur. J. Pharmacol. 243, 179.
  • CAS number 130717-51-0
  • ATP Competitive N
  • Form Pale yellow solid
  • Hill Formula CHNOS • HCl
  • Chemical formula CHNOS • HCl
  • Hygroscopic Hygroscopic
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target COX-1, COX-2 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 28 nM and 65 µ M for human recombinant COX-1 and COX-2
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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