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Merck - 239802-100MG - Curcumin, Curcuma longa L. | CAS 458-37-7 | Calbiochem | 100MG

  • MFR SKU: 239802-100MG
  • ITEM #: 19010130
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ITEM #: 19010130
Curcumin, Curcuma longa L.^ Inhibitor of 5-lipoxygenase (IC50=8uM) and cyclooxygenase (IC50=52uM). Has antitumor and anti-inflammatory properties. CAS: 458-37-7. FW: 368.4. Soluble in acetic acid and ethanol. Purity: >85% by HPLC. 100mg orange-yellow solid.
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Merck - 239802-100MG - Curcumin, Curcuma longa L. | CAS 458-37-7 | Calbiochem | 100MG

  • Item #: 19010130
  • MFR SKU: 239802-100MG
  • Overview A cell-permeable and irreversible antitumor and anti-inflammatory agent that acts as an inhibitor of 5-lipoxygenase (IC 50 = 8 µ M) and cyclooxygenase (IC 50 = 52 µ M). Confers significant protection against neurotoxic and genotoxic agents. Also inhibits the induction of nitric oxide synthase in activated macrophages (IC 50 = 6 µ M). Recently shown to inhibit the EGF receptor intrinsic kinase activity in the human epidermoid carcinoma A431 cells in a dose- and time-dependent manner. Also shown to be a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, inhibiting the acetylation of histones H3 and H4 with an IC 50 of ~25 µ M. Does not affect p300/CREB binding protein-associated factor (PCAF).
  • Catalogue Number 239802
  • Brand Family Calbiochem®
  • Synonyms 1, 7-Bis(4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione, Histone Acetyltransferase Inhibitor I, HAT Inhibitor I, p300/CBP Inhibitor I, NOD2 Signaling Inhibitor I, Nucleotide-binding Oligomerization Domain 2 Signaling Inhibitor I
  • References Hung, S., et al. 2008. Mol. Pharmacol. 74, 274.
  • Cui, L., et al. 2007. Antimicrob. Agents Chemother. 51, 488.
  • Salvioli, S., et al. 2007. eCAM 4, 181.
  • Balasubramanyam, K. et al. 2004. J. Biol. Chem. 279, 51163.
  • Brouet, I., and Okshima, H. 1995. Biochem. Biophys. Res. Commun. 206, 533.
  • Korutla, L., and Kumar, R. 1994. Biochim. Biophys. Acta 1224, 597.
  • Flynn, D.L., et al. 1986. Prostagland. Leuk. Med . 22, 357.
  • CAS number 458-37-7
  • ATP Competitive N
  • Form Orange-yellow solid
  • Hill Formula CHO
  • Chemical formula CHO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target 5-lipoxygenase 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 8 µ M, 52 µ M, against 5-lipoxygenase, Cyclooxygenase, respectively; 6 µ M inhibiting the induction of nitric oxide synthase in activated macrophages
  • Purity ≥ 80% by HPLC
  • Cell permeable Y
  • RTECS MI5230000
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +15° C to +30° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.

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