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Merck - 239804-100UG - Cyclopamine-KAAD | Calbiochem | 100UG

  • MFR SKU: 239804-100UG
  • ITEM #: 6281489
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ITEM #: 6281489
Cyclopamine- KAAD, CAS 306387-90-6, is a cell-permeable potent analog of Cyclopamine (Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC = 20 nM).
This listing is for 100 μg Glass bottle

Merck - 239804-100UG - Cyclopamine-KAAD | Calbiochem | 100UG

  • Item #: 6281489
  • MFR SKU: 239804-100UG
  • Overview A potent, cell-permeable analog of Cyclopamine (Cat. No. 239803 ) that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC 50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2 Ptch-/- cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. Also available as a 1 mM solution in DMSO (Cat. No. 239807 ).
  • Catalogue Number 239804
  • Brand Family Calbiochem®
  • Synonyms 3- K eto-N-( a minoethyl- a minocaproyl- d ihydrocinnamoyl)cyclopamine, KAAD-Cyclopamine, Shh Signaling Antagonist II
  • References Siegelin, M.D. et al. 2009. Neurobiol. Dis. 34, 259.
  • Watkins, D.N., et al. 2003. Nature 422, 313.
  • Berman, D.M., et al. 2002. Science 297, 1559.
  • Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
  • Chen, J.K., et al. 2002. Genes Dev. 16, 2743.
  • Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
  • Taipale, J., et al. 2000. Nature 406, 1005.
  • ATP Competitive N
  • Form Pale yellow solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Hh signaling in Shh-light2 assay 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 20 nM against Hedgehog (Hh) signaling in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells
  • Purity ≥ 70% by HPLC (sum of two isomers)
  • Cell permeable Y
  • R Phrase R: 20/21/22
  • Harmful by inhalation, in contact with skin and if swallowed.
  • S Phrase S: 22-36/37
  • Do not breathe dust.
  • Wear suitable protective clothing and gloves.
  • Ship Code Shipped with Blue Ice or with Dry Ice
  • Toxicity Harmful
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 2 weeks at -20° C.
  • Packaged under inert gas Packaged under inert gas

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