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Merck - 239807-50UG - InSolution Cyclopamine-KAAD | Calbiochem | 50 UG

  • MFR SKU: 239807-50UG
  • ITEM #: 11574915
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ITEM #: 11574915
InSolution™ Cyclopamine-KAAD, CAS 306387-90-6, is a 1 mM solution in DMSO. A cell-permeable, potent analog of Cyclopamine. Inhibits Hedgehog signaling (IC50 = 20 nM) with lower toxicity.
This listing is for 50 μg Glass bottle

Merck - 239807-50UG - InSolution Cyclopamine-KAAD | Calbiochem | 50 UG

  • Item #: 11574915
  • MFR SKU: 239807-50UG
Technical Specs
  • Overview A cell-permeable potent analog of Cyclopamine ( Cat. No. 239803 ) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC 50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2 Ptch-/- cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both ShhNp-induced pathway activity and SmoA1-induced reporter activity. Reported to cause regression of murine tumor allografts in vivo and induce rapid cell death in human medulloblastoma. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. The solid form of this compound (Cat. No. 239804 ) is also available.
  • Catalogue Number 239807
  • Brand Family Calbiochem®
  • Synonyms 3- K eto-N-( a minoethyl- a minocaproyl- d ihydrocinnamoyl)cyclopamine
  • References Siegelin, M.D. et al. 2009. Neurobiol. Dis. 34, 259.
  • Watkins, D.N., et al. 2003. Nature 422, 313.
  • Berman, D.M., et al. 2002. Science 297, 1559.
  • Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
  • Chen, J.K., et al. 2002. Genes Dev. 16, 2743.
  • Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
  • Taipale, J., et al. 2000. Nature 406, 1005.
  • Form Liquid
  • Formulation A 1 mM (50 µg/72 µ L) solution of Cyclopamine-KAAD ( Cat. No. 239804 ) in DMSO.
  • Hill Formula CHNlO
  • Hygroscopic Hygroscopic
  • Structure formula Image
  • Quality Level MQ100
  • Application InSolution™ Cyclopamine-KAAD, CAS 306387-90-6, is a 1 mM solution in DMSO. A cell-permeable, potent analog of Cyclopamine. Inhibits Hedgehog signaling (IC50 = 20 nM) with lower toxicity.
  • Primary Target SmoA1
  • Purity ≥ 70% by HPLC (sum of two isomers)
  • Cell permeable Y
  • R Phrase R: 36/38
  • Irritating to eyes and skin.
  • S Phrase S: 26-36/37/39
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing, gloves and eye/face protection.
  • Ship Code Dry Ice Only
  • Toxicity Irritant
  • Storage ≤ -70° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Avoid freeze/thaw Avoid freeze/thaw
  • Do not freeze Ok to freeze
  • Special Instructions Following initial thaw, aliquot and freeze (-70° C). Aliquots are stable for up to 6 months at -70° C.
  • Packaged under inert gas Packaged under inert gas
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