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Merck - 239822-10MG - CXCR4 Antagonist III (Fusin) | Calbiochem | 10 MG

  • MFR SKU: 239822-10MG
  • ITEM #: 11574918
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$390.50
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ITEM #: 11574918
The CXCR4 Antagonist III controls the biological activity of CXCR4. This small molecule/inhibitor is primarily used for Biochemicals applications.
This listing is for 10 mg Glass bottle

Merck - 239822-10MG - CXCR4 Antagonist III (Fusin) | Calbiochem | 10 MG

  • Item #: 11574918
  • MFR SKU: 239822-10MG
  • Overview A cell-permeable quinazoline compound that acts as a potent and reversible CXCR4 antagonist (IC 50 = 36.2 nM for SDF-1/CXCL12 binding to hCXCR4-transfected HEK293 membrane) with selectivity over closely related human chemokine receptors CXCR2, CCR2, CCR4 and CCR5 (IC 50 >10 µ M). Shown to inhibit CXCL12-induced Ca 2+ -mobilization and cell migration in hCXCR4-HEK293 cells (IC 50 = 100.1 and 41 nM, respectively), and rapidly mobilize CXCR4 + , CD34 + and CD133 + stem cells from bone marrow in C57BL/6 male mice (6 mg/kg, s.c).
  • Catalogue Number 239822
  • Brand Family Calbiochem®
  • Synonyms N²-(4-((3-(Cyclohexylamino)propylamino)methyl)benzyl)-N-(piperidin-4-yl) quinazoline-2, 4-diamine, 2HCl, Fusin Antagonist III
  • References Wu, C.H., et al. 2012. Chem. Med. Chem. 7, In press.
  • Form White solid
  • Hill Formula CHN• 2HCl
  • Chemical formula CHN• 2HCl
  • Hygroscopic Hygroscopic
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target CXCR4
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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