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Merck - 23-024M - p27 Protein complex, activated, 250 µg

  • MFR SKU: 23-024M
  • ITEM #: 11574832
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ITEM #: 11574832
Activated complex of three full length, recombinant human proteins: p27, Cyclin E1 & CDK2. Phosphorylated in vitro using CDK2/Cyclin E1. For use in Enzyme Assays.

Merck - 23-024M - p27 Protein complex, activated, 250 µg

  • Item #: 11574832
  • MFR SKU: 23-024M
  • Catalogue Number 23-024M
  • Brand Family Upstate
  • Trade Name
  • Upstate
  • p27 Protein complex, activated, 250 µg
  • Overview AXIS Axon Isolation Devices, 500 µm long channels, 10 devices
  • Alternate Names
  • p27 kip1
  • Cyclin-dependent kinase inhibitor 1B
  • Kip1
  • Background Information p27 is an important regulator of cell cycle progression, involved in G1 arrest. It is a potent inhibitor of cyclin E1- and cyclin A-CDK2 complexes and a positive regulator of cyclin D-dependent kinases such as CDK4. The degradation of this protein, which is triggered by its CDK-dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Decreased levels of p27 are found in various epithelial tumours originating from lung, breast, colon, ovary, oesophagus, thyroid and prostate. Defects in the gene encoding p27 (CDKN1B) are the cause of multiple endocrine neoplasia type 4 (MEN4) an inherited cancer of the thyroid.
  • Quality Level MQ100
  • Application Activated complex of three full length, recombinant human proteins: p27, Cyclin E1 & CDK2. Phosphorylated in vitro using CDK2/Cyclin E1. For use in Enzyme Assays.
  • Key Applications
  • Enzyme Assays
  • Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
  • Cascade Component Substrate
  • Entrez Gene Number
  • BC001971(p27)
  • NM_001798 (CDK2)
  • NM_001238 (Cyclin E1)
  • Purification Method Purified using immobilized metal affinity chromatography.
  • Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
  • Material Size 250 µg

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