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Merck - 23-028 - IkBa Protein, activated, 10 µg

  • MFR SKU: 23-028
  • ITEM #: 11574840
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ITEM #: 11574840
Activated, full length, recombinant human IκBα. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using IKKα, active. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.

Merck - 23-028 - IkBa Protein, activated, 10 µg

  • Item #: 11574840
  • MFR SKU: 23-028
Technical Specs
  • Catalogue Number 23-028
  • Brand Family Upstate
  • Trade Name
  • Upstate
  • IkBa Protein, activated, 10 µg
  • Overview N-terminal GST-tagged, recombinant human Smurf1 full length, expressed in E coli.
  • Alternate Names
  • NF-kappa-B inhibitor alpha
  • I-kappa-B-alpha
  • Major histocompatibility complex enhancer-binding protein MAD3
  • Background Information Iκ Bα is a cellular protein that inhibits the transcription factor NF-κ B. NF-κ B plays a central role in cellular stress and inflammatory responses by controlling cytokine-inducible gene expression and lymphocyte stimulation by antigens. In non-stimulated cells NF-κ B is sequestered in the cytoplasm via the inhibitory protein Iκ Bα, which obscures the nuclear localization signal of NF-κ B and also blocks its ability to bind DNA. In response to various stimuli, including viral infection, ultraviolet radiation and inflammatory cytokines, Iκ Bα is phosphorylated by the protein kinase complex IKK, which triggers its rapid degradation by ubiquitin mediated proteolysis. The liberated NF-κ B then translocates to the nucleus and activates the expression of target genes. Mutations in the gene for Iκ Bα result in the functional impairment of NF-κ B which causes a decreased production of proinflammatory cytokines and certain interferons, rendering patients susceptible to infection.
  • Quality Level MQ100
  • Application Activated, full length, recombinant human Iκ Bα. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using IKKα, active. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.
  • Key Applications
  • Enzyme Assays
  • Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
  • Cascade Component Substrate
  • Entrez Gene Number
  • M69043
  • Purification Method Purified using immobilized metal affinity chromatography.
  • Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
  • Material Size 10 µg
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