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Merck - 23-030 - 23-030, SCF-Fbw7 Protein Complex, Active, 10 µg Active complex of four (4) full length, recombinant human enzymes: Fbw7, Skp1, Cul1 & Rbx1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

  • MFR SKU: 23-030
  • ITEM #: 11592079
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ITEM #: 11592079
The SCF (Skp1-Cul1-F-bo x protein) comple x es represent the largest family of ubiquitin-protein ligases and mediate the ubiquitination of a broad spectrum of regulatory and signalling proteins in diverse cellular pathways. The SCF consists of three invariant components, Skp1, Cul1, and Rb x 1 and an interchangeable subunit, an F-bo x protein which is responsible for recruiting specific substrates to be ubiquitinated by the SCF. SCFFbw7 mediates the ubiquitination and subsequent proteasomal degradation...
ITEM #: 11592079
The SCF (Skp1-Cul1-F-bo x protein) comple x es represent the largest family of ubiquitin-protein ligases and mediate the ubiquitination of a broad spectrum of regulatory and signalling proteins in diverse cellular pathways. The SCF consists of three invariant components, Skp1, Cul1, and Rb x 1 and an interchangeable subunit, an F-bo x protein which is responsible for recruiting specific substrates to be ubiquitinated by the SCF. SCFFbw7 mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell division, growth and differentiation, including Cyclin E1, c-Myc, Notch and c-Jun. Mutations have been found in the Fbw7 subunit of SCFFbw7 in various types of human cancers, therefore Fbw7 is considered to be a potent tumour suppressor.
Synonyms: SCF Fb x w7, SCF hCdc4
Application: Ubiquitination Cascade Comoponent: E3
: UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
23-030, SCF-Fbw7 Protein Complex, Active, 10 µg Active complex of four (4) full length, recombinant human enzymes: Fbw7, Skp1, Cul1 & Rbx1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
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Merck - 23-030 - 23-030, SCF-Fbw7 Protein Complex, Active, 10 µg Active complex of four (4) full length, recombinant human enzymes: Fbw7, Skp1, Cul1 & Rbx1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

  • Item #: 11592079
  • MFR SKU: 23-030
Technical Specs
  • Catalogue Number 23-030
  • Brand Family Upstate
  • Trade Name
  • Upstate
  • SCF-Fbw7 Protein Complex, Active, 10 µg
  • Overview N-terminal c-Myc, 6His-tagged, recombinant human Smad7 full length, expressed by baculovirus in Sf21 insect cells.
  • Alternate Names
  • SCF Fbxw7
  • SCF hCdc4
  • Background Information The SCF (Skp1-Cul1-F-box protein) complexes represent the largest family of ubiquitin-protein ligases and mediate the ubiquitination of a broad spectrum of regulatory and signalling proteins in diverse cellular pathways. The SCF consists of three invariant components, Skp1, Cul1, and Rbx1 and an interchangeable subunit, an F-box protein which is responsible for recruiting specific substrates to be ubiquitinated by the SCF. SCF Fbw7 mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell division, growth and differentiation, including Cyclin E1, c-Myc, Notch and c-Jun. Mutations have been found in the Fbw7 subunit of SCF Fbw7 in various types of human cancers, therefore Fbw7 is considered to be a potent tumour suppressor.
  • Quality Level MQ100
  • Application Active complex of four (4) full length, recombinant human enzymes: Fbw7, Skp1, Cul1 & Rbx1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
  • Key Applications
  • Enzyme Assays
  • Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
  • Cascade Component E3
  • Entrez Gene Number
  • NM_033632 (Fbw7)
  • NM_170679 (Skp1)
  • NM_003592 (Cul1)
  • NM_014248 (Rbx1)
  • Purification Method Purified using glutathione sepharose.
  • Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
  • Material Size 10 µg
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