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Merck - 23-034M - 23-034M, p53 Protein, 10 µg Full length, recombinant human p53. N-terminal c-Myc, 6His-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.

  • MFR SKU: 23-034M
  • ITEM #: 11574851
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ITEM #: 11574851
p53 is e x pressed in a wide variety of tissues and plays a major role in preventing tumour development. It is involved in cell cycle regulation, functioning as a trans-activator to negatively regulate cell division by controlling a set of genes required for this process. It acts as a tumour suppressor in many tumour types by stimulating either apoptosis or growth arrest depending on the physiological circumstances and the cell type. Defects in p53 e x pression have been implicated in several diseases...
ITEM #: 11574851
p53 is e x pressed in a wide variety of tissues and plays a major role in preventing tumour development. It is involved in cell cycle regulation, functioning as a trans-activator to negatively regulate cell division by controlling a set of genes required for this process. It acts as a tumour suppressor in many tumour types by stimulating either apoptosis or growth arrest depending on the physiological circumstances and the cell type. Defects in p53 e x pression have been implicated in several diseases including; choroid ple x us papilloma, lung cancer, head/neck squamous cell carcinomas, oesophageal squamous cell carcinoma, Li-Fraumeni syndrome, and hereditary adrenocortical carcinoma.
Synonyms: Cellular tumour antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumour suppressor p53, TP53
Application: Ubiquitination Cascade Comoponent: Substrate
: UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
23-034M, p53 Protein, 10 µg Full length, recombinant human p53. N-terminal c-Myc, 6His-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.
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Merck - 23-034M - 23-034M, p53 Protein, 10 µg Full length, recombinant human p53. N-terminal c-Myc, 6His-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.

  • Item #: 11574851
  • MFR SKU: 23-034M
Technical Specs
  • Catalogue Number 23-034M
  • Brand Family Upstate
  • Trade Name
  • Upstate
  • p53 Protein, 250 µg
  • Alternate Names
  • Cellular tumour antigen p53
  • Antigen NY-CO-13
  • Phosphoprotein p53
  • Tumour suppressor p53
  • TP53
  • Background Information p53 is expressed in a wide variety of tissues and plays a major role in preventing tumour development. It is involved in cell cycle regulation, functioning as a trans-activator to negatively regulate cell division by controlling a set of genes required for this process. It acts as a tumour suppressor in many tumour types by stimulating either apoptosis or growth arrest depending on the physiological circumstances and the cell type. Defects in p53 expression have been implicated in several diseases including; choroid plexus papilloma, lung cancer, head/neck squamous cell carcinomas, oesophageal squamous cell carcinoma, Li-Fraumeni syndrome, and hereditary adrenocortical carcinoma.
  • Quality Level MQ100
  • Application Full length, recombinant human p53. N-terminal c-Myc, 6His-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.
  • Key Applications
  • Enzyme Assays
  • Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
  • Cascade Component Substrate
  • Entrez Gene Number
  • BC003596
  • Purification Method Purified using immobilized metal affinity chromatography.
  • Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
  • Material Size 250 µg
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