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Merck - 23-041 - 23-041, c-Cbl Protein, active, 10 µg Active, full length, recombinant human c-Cbl. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

MFR SKU: 23-041

ITEM #: 11574858

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$861.85

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ITEM #: 11574858
N-terminal cMyc and GST-tagged, recombinant human IKKgamma full length, e x pressed by baculovirus in Sf21 insect cells.
Synonyms: E3 ubiquitin-protein ligase CBL, Casitas B-lineage lymphoma proto-oncogene, RING finger protein 55, Signal transduction protein CBL, CBL2, RNF55
Application: Ubiquitination Cascade Comoponent: E3
: UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
23-041, c-Cbl Protein, active, 10 µg Active, full length, recombinant human c-Cbl. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
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Merck - 23-041 - 23-041, c-Cbl Protein, active, 10 µg Active, full length, recombinant human c-Cbl. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

Item #: 11574858

MFR SKU: 23-041

Technical Specs

Catalogue Number 23-041
Brand Family Upstate
Trade Name

Upstate

c-Cbl Protein, active, 10 µg
Overview N-terminal cMyc and GST-tagged, recombinant human IKKγ full length, expressed by baculovirus in Sf21 insect cells.
Alternate Names

E3 ubiquitin-protein ligase CBL
Casitas B-lineage lymphoma proto-oncogene
RING finger protein 55
Signal transduction protein CBL
CBL2
RNF55

Background Information Intracellular signals mediated by receptor tyrosine kinases play a pivotal role in morphogenesis, cell fate determination and pathogenesis. c-Cbl is a ubiquitin ligase (E3) that facilitates the regulation of these pathways, attenuating signalling through ubiquitination and subsequent protein degradation. c-Cbl contains several functional domains, including a tyrosine kinase-binding domain that associates with a number of protein tyrosine kinases in a phosphorylation-dependent manner, a catalytic RING-finger domain that interacts with E2s and is essential for E3 activity and a C-terminal proline rich domain which mediates interactions with SH3 containing proteins. Mutations in the gene for c-Cbl have been implicated in a number of human cancers, particularly acute myeloid leukaemia.

Quality Level MQ100
Application Active, full length, recombinant human c-Cbl. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
Key Applications

Enzyme Assays

Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Cascade Component E3
Entrez Gene Number

NM_005188

Purification Method Purified using glutathione sepharose.
Usage Statement

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Material Size 10 µg

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Merck - 23-041 - 23-041, c-Cbl Protein, active, 10 µg Active, full length, recombinant human c-Cbl. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

Merck - 23-041 - 23-041, c-Cbl Protein, active, 10 &micro;g Active, full length, recombinant human c-Cbl. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

Technical Specs

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Merck - 23-041 - 23-041, c-Cbl Protein, active, 10 µg Active, full length, recombinant human c-Cbl. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.