Merck - 23-044M - 23-044M, VHL Protein Complex, Active, 10 µg Active complex of five (5) recombinant human enzymes: VHL amino acids 54-end, full length Elongin C, full length Elongin B, full length Cul2, & full length Rbx1. For use in Enzyme Assays.

ITEM #: 11574864
The VHL comple x is a multi-subunit ubiquitin ligase composed of VHL, Elongin B, Elongin C, Cul2 and Rb x 1. The VHL protein serves as the substrate recognition component and is linked by Elongin C to a heterodimeric Cul2/Rb x 1 module that functions as a potent activator of the ubiquitination of target proteins by an E2 conjugating enzyme. Elongin B interacts with the comple x through Elongin C and appears to stabilize the binding of Elongin C to VHL. The primary function of the VHL comple x is to regulate HIF (hypo x ia inducible factor) activity by targeting the hydro x ylated HIF-1alpha subunit for ubiquitination and rapid proteasomal degradation under normo x ic conditions. It therefore plays an important role in the regulation of hypo x ia-inducible genes such as the vascular endothelial growth factor (VEGF) and glucose transport-1 (Glut-1). Mutations in VHL are associated with the inherited von Hippel-Lindau (VHL) cancer syndrome and numerous forms of renal cell carcinoma.
Synonyms: VCB-Cul2 comple x , ECV comple x , CBC VHL
Application: Ubiquitination Cascade Comoponent: E3
: UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
23-044M, VHL Protein Complex, Active, 10 µg Active complex of five (5) recombinant human enzymes: VHL amino acids 54-end, full length Elongin C, full length Elongin B, full length Cul2, & full length Rbx1. For use in Enzyme Assays. Functions as an E3
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