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Merck - 23-045M - HIF-1 Protein, 250 µg

  • MFR SKU: 23-045M
  • ITEM #: 11574866
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ITEM #: 11574866
Recombinant human HIF-1α amino acids 331-609, N-terminal c-Myc, GST-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.

Merck - 23-045M - HIF-1 Protein, 250 µg

  • Item #: 11574866
  • MFR SKU: 23-045M
  • Catalogue Number 23-045M
  • Brand Family Upstate
  • Trade Name
  • Upstate
  • HIF-1α Protein, 250 µg
  • Alternate Names
  • Hypoxia-inducible factor 1-alpha
  • ARNT-interacting protein
  • Basic-helix-loop-helix-PAS protein MOP1
  • bHLHe78
  • PAS domain-containing protein 8
  • Background Information HIF-1α is the oxygen sensitive subunit of the hypoxia inducible factor HIF-1 which is an essential mediator of the cellular oxygen-signalling pathway. Under hypoxic conditions HIF-1α activates the transcription of over 40 genes, including those that control glucose uptake, metabolism, angiogenesis, erythropoiesis, cell proliferation, and apoptosis. The expression of HIF-1α is commonly increased in a variety of human tumours, and correlates with poor patient prognosis. Under normoxia this protein interacts with the ubiquitin ligase VHL complex, leading to its polyubiquitination and subsequent proteasomal degradation.
  • Quality Level MQ100
  • Application Recombinant human HIF-1α amino acids 331-609, N-terminal c-Myc, GST-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.
  • Key Applications
  • Enzyme Assays
  • Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
  • Cascade Component Substrate
  • Entrez Gene Number
  • NM_001530
  • Purification Method Purified using glutathione sepharose.
  • Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
  • Material Size 250 µg

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